86795-49-5Relevant articles and documents
Iodonium Ylides as Carbene Precursors in Rh(III)-Catalyzed C-H Activation
Jiang, Yuqin,Li, Pengfei,Li, Xingwei,Liu, Bingxian,Zhao, Jie
supporting information, p. 7475 - 7479 (2020/10/12)
The rhodium(III)-catalyzed coupling of C-H substrates with iodonium ylides has been realized for the efficient synthesis of diverse cyclic skeletons, where the iodonium ylides have been identified as efficient and outstanding carbene precursors. The reaction systems are applicable to both sp2 and sp3 C-H substrates under mild and redox-neutral conditions. The catalyst loading can be as low as 0.5 mol % in a gram-scale reaction. Representative products exhibit cytotoxicity toward human cancer cells at nanomolar levels.
Hypervalent Iodine(III)-Mediated Tosyloxylation of 4-Hydroxycoumarins
Xu, Bowen,Gao, Yiping,Han, Jianwei,Xing, Zejing,Zhao, Sihan,Zhang, Ziyang,Ren, Runlin,Wang, Limin
, p. 10136 - 10144 (2019/09/04)
An efficient approach was developed for synthesis of 3-tosyloxy-4-hydroxycoumarins under mild conditions by using Koser's reagents. The reaction tolerated various functional groups, and the products served as useful aromatic building blocks. Additionally, a plausible mechanism via iodonium ylide was proposed, and the oral anticoagulant Warfarin was synthesized in good yield.
Antitrypanosomal and antioxidant properties of 4-hydroxycoumarins derivatives
Perez-Cruz, Fernanda,Serra, Silvia,Delogu, Giovanna,Lapier, Michel,Maya, Juan Diego,Olea-Azar, Claudio,Santana, Lourdes,Uriarte, Eugenio
experimental part, p. 5569 - 5573 (2012/09/25)
In the present communication we prepared a series of six 4-hydroxycoumarin derivatives, isosters of quercetin, recognized as an antioxidant natural compound, with the aim of evaluating the antitrypanosomal activity against Trypanosoma cruzi, the parasite
