86796-12-5

Basic information

• Product Name: 1-Acetyl-2-hydroxy-4-chinolizinon
• Synonyms: 1-Acetyl-2-hydroxy-4-chinolizinon
• CAS NO: 86796-12-5
• Molecular Weight: 203.197
• Mol File: 86796-12-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Acetyl-2-hydroxy-4-chinolizinon(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Acetyl-2-hydroxy-4-chinolizinon(86796-12-5)
• EPA Substance Registry System: 1-Acetyl-2-hydroxy-4-chinolizinon(86796-12-5)

Safety Data

• Hazardous Substances Data: 86796-12-5(Hazardous Substances Data)

Upstream product

• 6302-02-9 2-acetonylpyridine 
• 15781-70-1 malonic acid bis-(2,4,6-trichloro-phenyl) ester 

Relevant articles and documents

Quinolizines and Indolizines, XIII. Acyl-2-hydroxy-4-quinolizinones

The reaction of 2-picolylketones (1a, b) with reactive trichlorophenyl malonates (2a-f) leads to 1-acyl-2-hydroxy-4-quinolizinones (3a-i) which can be easily deacylated by boiling hydrochloric acid yielding 4-quinolizinones 4a-f.The 3-acetyl-2-hydroxy-4-quinolizinones 6 and 8 are obtained by Klosa-Ziegler acylation of 4a and 7, respectively.The reaction of the acetyl compound 3a with acetic anhydride yields the 2-pyrone derivative 9, whereas the propionyl derivative 3g yields the 4-pyrone 10 under the same conditions.Nitration of 3e does not give the 1-nitro derivative 12 but rather the 1,3-dinitro compound 11. - Keywords: 3-Acetyl-2-hydroxy-4-quinolizinones; 1-Acyl-2-hydroxy-4-quinolizinones; Bis-2,4,6-trichlorophenyl malonates; Deacylation; Klosa-Ziegler-acylation