868077-44-5

Basic information

• Product Name: 1-(5-Nitro-2-pyridinyl)piperidine-4-carboxylic acid
• Synonyms: 4-Carboxy-1-(5-nitropyridin-2-yl)piperidine, 2-(4-Carboxypiperidin-1-yl)-5-nitropyridine;1-(5-NITRO-2-PYRIDINYL)PIPERIDINE-4-CARBOXYLIC ACID;1-(5-NITRO-2-PYRIDINYL)PIPERIDINE-4-CARBOXYLIC ACID(WX160444)
• CAS NO: 868077-44-5
• Molecular Formula: C₁₁H₁₃N₃O₄
• Molecular Weight: 251.24
• Mol File: 868077-44-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 504.9ºC at 760 mmHg
• Flash Point: 259.2ºC
• Appearance: /
• Density: 1.403g/cm3
• Vapor Pressure: 5.13E-11mmHg at 25°C
• Refractive Index: 1.606
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(5-Nitro-2-pyridinyl)piperidine-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-Nitro-2-pyridinyl)piperidine-4-carboxylic acid(868077-44-5)
• EPA Substance Registry System: 1-(5-Nitro-2-pyridinyl)piperidine-4-carboxylic acid(868077-44-5)

Safety Data

• Hazardous Substances Data: 868077-44-5(Hazardous Substances Data)

Usage

General Description

1-(5-Nitro-2-pyridinyl)piperidine-4-carboxylic acid is a chemical compound that contains a nitro group, a pyridine ring, a piperidine ring, and a carboxylic acid functional group. It is used in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. The presence of the nitro group and the piperidine ring imparts this compound with unique reactivity and biological activity, making it useful in the development of new drugs and other bioactive molecules. It is important to handle and store this compound with caution, as nitro groups can be explosive under certain conditions.

InChI:InChI=1/C11H13N3O4/c15-11(16)8-3-5-13(6-4-8)10-2-1-9(7-12-10)14(17)18/h1-2,7-8H,3-6H2,(H,15,16)

Upstream product

• 498-94-2 isonipecotic acid 
• 4548-45-2 2-chloro-5-nitropyridine 

Downstream Products

• 868077-45-6 (4-[3-piperidinopropoxy]phenyl)-(1-[5-nitropyridin-2-yl]piperidin-4-yl)methanone 

Relevant articles and documents

Search for histamine H3 receptor antagonists with combined inhibitory potency at Nτ-methyltransferase: Ether derivatives

With the recent development of new hybrid compounds having histamine H 3 receptor antagonist with combined histamine Nτ- methyltransferase (HMT) inhibitory potency an innovative approach was described in the research of novel lead compounds modulating histaminergic neurotransmission. Several compounds containing an ether moiety derived from the recently published 4-(3-piperidinopropoxy)phenylaminoquinoline derivatives (like FUB 836), were synthesized in this study and tested for their affinity at cloned human histamine H3 (hH3) receptors and on the inhibition of rat HMT. Besides different heterocycles, e.g. nitro- or amino-substituted pyridines, quinolines, benzothiazole or pyrroline, three classes of compounds were produced: heteroaromatic 3-piperidinopropyl ethers, keto- or imino-substituted 4-(3-piperidinopropyl)phenyl ethers and 4-(3-piperidinopropyl)phenyl ethers with substituted (alkyl)aminopyridines. Whereas the (3-piperidinopropoxy)heterocycles showed only moderate activities on both test models, the 4-(3-piperidinopropoxy)phenyl derivatives were identified as potent histamine H3 receptor ligands and/or HMT inhibitors. Ki values up to 0.42 nM were found for the affinity to the hH 3 receptor. HMT inhibitory potency was identified with IC 50 values about 0.3 μM for the most potent compounds in this series. Comparison of the pyridine-containing derivatives to recently published quinoline analogues showed a decrease in potencies for the pyridines. The dual activity, H3 receptor affinity and HMT inhibition, was moderate to good. For all compounds affinities at hH3 receptors were higher than their inhibitory HMT potencies. The described new histamine H3 receptor antagonists with an ether moiety represent a further promising step in our investigations for a dual activity.