86827-23-8Relevant articles and documents
38. Approaches to the Synthesis of Cytochalasans. Part 4. Improved Synthesis of the Tetrahydroisoindoline Subunits Related to the Cytochalasins and Aspochalasins
Schmidlin, Tibur,Bruckhardt, Peter E.,Waespe-Sarcevic, Nada,Tamm, Christoph
, p. 450 - 465 (2007/10/02)
A general scheme for the synthesis of the tetrahydroisoindolinone moiety of naturally occurring cytochalasans and unnatural analogs was developed.The keystep consist of the intermolecular cycloaddition of 4-methylsorbinol (7) to an alkylidene malonic