86843-26-7

Basic information

• Product Name: 6-[5-(1-Cyclohexyl-1H-tetrazol-5-yl)-pentyloxy]-3,4-dihydro-1H-quinolin-2-one
• CAS NO: 86843-26-7
• Molecular Weight: 383.494
• Mol File: 86843-26-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-[5-(1-Cyclohexyl-1H-tetrazol-5-yl)-pentyloxy]-3,4-dihydro-1H-quinolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-[5-(1-Cyclohexyl-1H-tetrazol-5-yl)-pentyloxy]-3,4-dihydro-1H-quinolin-2-one(86843-26-7)
• EPA Substance Registry System: 6-[5-(1-Cyclohexyl-1H-tetrazol-5-yl)-pentyloxy]-3,4-dihydro-1H-quinolin-2-one(86843-26-7)

Safety Data

• Hazardous Substances Data: 86843-26-7(Hazardous Substances Data)

Upstream product

• 54197-66-9 3,4-dihydro-6-hydroxy-2(1H)-quinolinone 
• 78760-14-2 5-(5-Chloro-pentyl)-1-cyclohexyl-1H-tetrazole 

Relevant articles and documents

Studies on 2-oxoquinoline derivatives as blood platelet aggregation inhibitors. II. 6-[3-(1-Cyclohexyl-5-tetrazolyl)propoxy]-1,2-dihydro-2-oxoquinoline and related compounds

A series of ω-(1-substituted-5-tetrazolylalkoxy)-2-oxoquinolines was synthesized and tested for inhibitory activity towards collagen- and adenosine diphosphate (ADP)-induced aggregation of rabbit blood platelets in vitro. These compounds were prepared by the reaction of 1-substituted-5-(ω-chloroalkyl)-tetrazoles and hydroxy-2-oxoquinolines in the presence of a base. Among them, 6-[3-(1-cyclohexyl-5-tetrazolyl)propoxy]-1,2-dihydro-2-oxoquinoline (IVb) was found to have the most potent inhibitory activity. The structure-activity relationships are discussed.