86906-05-0

Basic information

• Product Name: (R)-(+)-2-AMINO-1,1,3-TRIPHENYL-1-PROPANOL
• Synonyms: (2R)-1,1,3-Triphenyl-2-amino-1-propanol;(R)-2-Amino-1,1,3-triphenyl-1-propanol,99%e.e.;(R)-(+)-2-AMINO-1,1,3-TRIPHENYL-1-PROPANOL
• CAS NO: 86906-05-0
• Molecular Formula: C₂₁H₂₁NO
• Molecular Weight: 303.4
• Product Categories: Amino Alcohols;Chiral Building Blocks;Organic Building Blocks
• Mol File: 86906-05-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 142-144 °C(lit.)
• Boiling Point: 502.3 ºC at 760 mmHg
• Flash Point: 257.6 ºC
• Appearance: /
• Density: 1.145 g/cm³
• Vapor Pressure: 6.57E-11mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: (R)-(+)-2-AMINO-1,1,3-TRIPHENYL-1-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-2-AMINO-1,1,3-TRIPHENYL-1-PROPANOL(86906-05-0)
• EPA Substance Registry System: (R)-(+)-2-AMINO-1,1,3-TRIPHENYL-1-PROPANOL(86906-05-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 86906-05-0(Hazardous Substances Data)

Usage

General Description

"(R)-(+)-2-Amino-1,1,3-triphenyl-1-propanol" is a chemical compound with synthetic value in industrial and pharmaceutical applications. It belongs to the category of chiral amines, a class of compounds that play a critical role in medicinal chemistry due to their wide biological activities. Known for its chirality, or its property of having non-superimposable mirror images, this compound is of significant interest in the field of stereochemistry. Its R-configuration denotes its specific orientation, a crucial factor in determining how it interacts with other molecules. The compound's triphenyl structure suggests high stability and potential affinity for aromatic interactions, while its amino and hydroxyl groups contribute to its reactivity.

InChI:InChI=1/C21H21NO/c22-20(16-17-10-4-1-5-11-17)21(23,18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-15,20,23H,16,22H2/t20-/m1/s1

Upstream product

• 13033-84-6 D-phenylalanine methyl ester hydrochloride 
• 100-58-3 phenylmagnesium bromide 
• 57728-37-7 DL-2-Amino-1,1,3-triphenyl-1-propanol 
• 21685-51-8 D-phenylalanine methyl ester 
• 673-06-3 D-(R)-phenylalanine 

Downstream Products

• 1318762-59-2 (S,S)-2-amino-N-(1-hydroxy-1,1,3-triphenylpropan-2-yl)-3-methylbutanamide 
• 1318762-61-6 (S,R)-2-amino-N-(1-hydroxy-1,1,3-triphenylpropan-2-yl)-4-methylpentanamide 
• 57728-37-7 DL-2-Amino-1,1,3-triphenyl-1-propanol 
• 1399169-34-6 C₈₂H₆₀N₂O₂ 
• 1023625-72-0 2-hydroxybenzaldehyde ((2R)-1,1,3-triphenylpropanol) imine 
• 694520-62-2 1-((R)-4-Benzyl-5,5-diphenyl-2-thioxo-oxazolidin-3-yl)-2-{(2S,5S)-5-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-pentyl]-tetrahydro-furan-2-yl}-ethanone 
• 694520-57-5 (R)-N-acetyl-4,4-diphenyl-5-benzyloxazolidin-2-thione 
• 191274-51-8 (R)-4,4-diphenyl-5-benzyloxazolidin-2-thione 

Relevant articles and documents

Direct asymmetric N-specific reaction of nitrosobenzene with aldehydes catalyzed by a chiral primary amine-based organocatalyst

Nitroso compounds have two reactive nitrogen and oxygen atoms. It is interesting and important to perform a nitrogen or oxygen selective reaction with interesting substrates. These atom specific reactions are crucial to specifically synthesis of specific compounds. An enantioselective N-specific reaction of nitrosobenzene with unmodified aldehydes was successfully achieved catalyzed first by a variety of primary amine-based organocatalysts with higher yield and enantioselectivity. The bulkier substituted groups of the organocatalyst and two hydrogen bonds from the organocatalyst and the oxygen atom of nitrosobenzene make the reaction preferentially N-specific and predominantly afford R products.

Highly Diastereoselective Synthesis of trans-2,5-Disubstituted Tetrahydrofurans

trans-2,5-Disubstituted tetrahydrofurans were obtained as major diastereomers (trans / cis ratio 90:10-100: 0) when acetylated y-lactols derived from (S)-glutamic acid were treated with titanium enolates of N-acetyl (R)-oxazolidin-2-thiones. A simple tran