869186-47-0

Basic information

• Product Name: (2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-hydroxypropyl)phenyl)-2-propoxy)tetrahydropyran
• Synonyms: (2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-hydroxypropyl)phenyl)-2-propoxy)tetrahydropyran
• CAS NO: 869186-47-0
• Molecular Weight: 542.118
• Mol File: 869186-47-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-hydroxypropyl)phenyl)-2-propoxy)tetrahydropyran(CAS DataBase Reference)
• NIST Chemistry Reference: (2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-hydroxypropyl)phenyl)-2-propoxy)tetrahydropyran(869186-47-0)
• EPA Substance Registry System: (2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-hydroxypropyl)phenyl)-2-propoxy)tetrahydropyran(869186-47-0)

Safety Data

• Hazardous Substances Data: 869186-47-0(Hazardous Substances Data)

Downstream Products

• 162489-71-6 (2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-methanesulfonylpropyl)phenyl)-2-propoxy)tetrahydropyran 
• 1000788-70-4 1-(((1-(R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-((1-tetrahydropyranyloxy)-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropyl acetate 
• 158966-92-8 montelukast 
• 151767-02-1 Montelukast sodium 

Relevant articles and documents

And Menlust sodium process for the preparation of intermediates

The invention relates to a method suitable for preparing montelukast sodium and intermediate 2-(3(S)-(3-(2-(7-chlorine-2-quinolyl) vinyl) phenyl)-3-hydroxypropyl) phenyl)-2-propoxy) tetrahydropyrane (intermediate 3) of the montelukast sodium in a large scale. According to the method, 7-chloroquinaldine and 3-cyanobenzaldehyde are used as starting raw materials, 2-(3-(3-(2-(7-chlorine-2-quinolyl) vinyl) phenyl)-3-oxopropyl) phenyl)-2-propoxy) tetrahydropyrane (intermediate 2) is obtained by six steps of reaction, then intermediate 3 with ee more than 99% and yield more than 90% is obtained by chiral reduction, and the montelukast sodium with high optical purity and high chemical purity is obtained by the intermediate 3 through four steps of reaction.