86923-98-0

Basic information

• Product Name: BETA-NERVE GROWTH FACTOR, HUMAN
• Synonyms: HUMAN B-NGF;HUMAN BETA NERVE GROWTH FACTOR;HUMAN BETA-NGF;HUMAN BETA-NGF PROBE;HUMAN NGF-BETA;BETA-NGF (HUMAN);BETA-NERVE GROWTH FACTOR, HUMAN;BETA-NERVE GROWTH FACTOR, HUMAN, RECOMBINANT
• CAS NO: 86923-98-0
• Molecular Weight: 0
• Mol File: 86923-98-0.mol
• Article Data: 0

Chemical Properties

• Appearance: /lyophilized powder
• Storage Temp.: −20°C
• CAS DataBase Reference: BETA-NERVE GROWTH FACTOR, HUMAN(CAS DataBase Reference)
• NIST Chemistry Reference: BETA-NERVE GROWTH FACTOR, HUMAN(86923-98-0)
• EPA Substance Registry System: BETA-NERVE GROWTH FACTOR, HUMAN(86923-98-0)

Safety Data

• Safety Statements: WGK Germany : 3:
• WGK Germany: 3
• Hazardous Substances Data: 86923-98-0(Hazardous Substances Data)

Usage

Description

BETA-NERVE GROWTH FACTOR, HUMAN, also known as NGF-β, is a protein that plays a crucial role in signal transduction and is expressed by various tissues, including the placenta, urothelium, and bladder smooth muscle cells. As a neurotrophin and a member of the NGF family, it is essential for the growth, maintenance, and survival of certain target neurons.

Uses

Used in Protein Pin Arrays:
BETA-NERVE GROWTH FACTOR, HUMAN is used as a component in protein pin arrays for the purpose of studying its interactions with other proteins and understanding its role in various biological processes.
Used in Cancer Research:
In the field of cancer research, BETA-NERVE GROWTH FACTOR, HUMAN is used to induce U87-MG (glioblastoma cell line) cell proliferation. This application helps researchers investigate the role of NGF-β in cancer development and progression, as well as its potential as a therapeutic target.
Used in Drug Release Kinetics:
BETA-NERVE GROWTH FACTOR, HUMAN is also utilized in the study of drug release kinetics, where it can provide insights into the behavior of drugs and their delivery systems, ultimately contributing to the development of more effective treatments.

Biochem/physiol Actions

NGFβ (nerve growth factor β) is essential for the differentiation and survival of neurons. It also plays a key role in the development and maintenance of nervous system. It is also involved in angiogenesis, and facilitates tumorigenesis such as, oral, breast and prostate cancers. It has potential as marker for the diagnosis of interstitial cystitis/painful bladder syndrome (IC/PBS) and overactive bladder (OAB), and might also aid in determining the therapy for the same. It might be involved in changes in placental function, as NGF signaling is influenced by antenatal depression and selective serotonin reuptake inhibitor (SSRI) treatment.