869290-30-2Relevant articles and documents
Use of silyl ester and enamine protection for an efficient alternate synthesis of (1S,2S,5R,6S)-2-[(2′S)-(2′-amino)propionyl] aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid hydrochloride (LY544344·HCl)
Fennell, Jared W.,Semo, Michael J.,Wirth, David D.,Vaid, Radhe K.
, p. 2659 - 2664 (2006)
An alternate synthesis of title compound (5) using N-(2-methoxycarbonyl-1- methylvinyl)-L-alanine sodium salt (6) and 2-aminobicyclo[3.1.0]hexane-2,6- dicarboxylic acid (1) was successfully completed. Incorporation of silyl ester protection and the use of an enamine-protecting group allowed for the elimination of several processing steps. Georg Thieme Verlag Stuttgart.