869478-09-1

Basic information

• Product Name: 8-acetyl-6-(benzyloxy)-2H-benzo[b][1,4]oxazin-3(4H)-one
• Synonyms: 8-acetyl-6-(benzyloxy)-2H-benzo[b][1,4]oxazin-3(4H)-one;2H-1,4-Benzoxazin-3(4H)-one, 8-acetyl-6-(phenylMethoxy)-;8-acetyl-6-benzyloxy-4H-benzo[1,4]oxazin-3-one;8-acetyl-6-(phenylmethoxy)-2H-1,4-benzoxazin-3(4H)-one
• CAS NO: 869478-09-1
• Molecular Formula: C₁₇H₁₅NO₄
• Molecular Weight: 297.3053
• Mol File: 869478-09-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 517.2±50.0 °C(Predicted)
• Appearance: /
• Density: 1.259±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Chloroform, DCM, Methanol
• PKA: 11.84±0.20(Predicted)
• CAS DataBase Reference: 8-acetyl-6-(benzyloxy)-2H-benzo[b][1,4]oxazin-3(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8-acetyl-6-(benzyloxy)-2H-benzo[b][1,4]oxazin-3(4H)-one(869478-09-1)
• EPA Substance Registry System: 8-acetyl-6-(benzyloxy)-2H-benzo[b][1,4]oxazin-3(4H)-one(869478-09-1)

Safety Data

• Hazardous Substances Data: 869478-09-1(Hazardous Substances Data)

Usage

Uses

8-Acetyl-6-benzyloxy-4H-benzo[1,4]oxazin-3-one is an intermediate in the synthesis of Olodaterol (O262000), a novel inhaled β2-adrenoceptor agonist with a 24h bronchodilatory efficacy.

Upstream product

• 1205-91-0 benzene-1,4-diyl diacetate 
• 123-31-9 hydroquinone 
• 131341-58-7 2,5'-dihydroxy acetophenone 
• 100-44-7 benzyl chloride 
• 490-78-8 2,5-Dihydroxyacetophenone 
• 30992-63-3 5-benzyloxy-2-hydroxyacetophenone 
• 861841-94-3 1‐[2-hydroxy-3-nitro-5-(benzyloxy)phenyl]ethanone 
• 100-39-0 benzyl bromide 
• 861841-90-9 1-[2-hydroxy-3-amino-5-(benzyloxy)phenyl]ethanone 
• 75-36-5 acetyl chloride 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 869478-12-6 8-(2R)-oxirane-6-(phenylmethoxy)-2H-1,4-benzoxazine-3(4H)-one 
• 693273-07-3 6-(benzyloxy)-8-(2,2-dihydroxyacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 926319-53-1 8-(bromoacetyl)-6-(phenylmethoxy)-2H-1,4-benzoxazin-3(4H)-one 
• 869478-10-4 6-benzyloxy-8-(2-chloro-acetyl)-4H-benzo[1,4]oxazin-3-one 

Relevant articles and documents

CLASS OF BIFUNCTIONAL COMPOUNDS WITH QUATERNARY AMMONIUM SALT STRUCTURE

The invention provides a class of compounds represented by formula (I), having bifunctional active quaternary ammonium salt structure of a β2-adrenoreceptor agonist and an M receptor antagonist, a pharmaceutically acceptable salt, solvate, and optical isomer thereof. A pharmaceutical composition comprising such a compound with quaternary ammonium salt structure, a method for preparing such a compound with quaternary ammonium salt structure and an intermediate thereof, and uses thereof in treating pulmonary disorders are also provided. The compounds of the invention have high selectivity to the M receptor subtype, and have less adverse reaction and lower toxic and side effects in the treatment of pulmonary diseases such as COPD and asthma.

Benzoxazine compound and its preparation methods and application

The invention relates to a benzoxazine compound represented in the following formula 1. The benzoxazine compound can serve as a beta 2 receptor agonist. The formula can be seen from the description.

PROCESS FOR THE MANUFACTURING OF BETA MIMETICS

The invention relates to a method for producing betamimetics of formula (1), wherein in which n represents 1 or 2; R1 represents hydrogen, halogen, C1-4-alkyl or O—C1-4-alkyl; R2 represents hydrogen, halogen, C