870063-52-8

Basic information

• Product Name: 2-CHLORO-5-FLUORO-3-(HYDROXYMETHYL)PYRIDINE
• Synonyms: 2-Chloro-5-flioro-3-(hydroxymethyl)pyridine;(2-Chloro-5-fluoro-3-pyridyl)methanol;(2-CHLORO-5-FLUORO-PYRIDIN-3-YL)-METHANOL;2-CHLORO-5-FLUORO-3-(HYDROXYMETHYL)PYRIDINE
• CAS NO: 870063-52-8
• Molecular Formula: C₆H₅ClFNO
• Molecular Weight: 161.56
• Product Categories: Boronic Acid
• Mol File: 870063-52-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 253.6 °C at 760 mmHg
• Flash Point: 107.2 °C
• Appearance: /
• Density: 1.434g/cm³
• Vapor Pressure: 0.00942mmHg at 25°C
• Refractive Index: 1.546
• Storage Temp.: 2-8°C
• PKA: 12.61±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-5-FLUORO-3-(HYDROXYMETHYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-FLUORO-3-(HYDROXYMETHYL)PYRIDINE(870063-52-8)
• EPA Substance Registry System: 2-CHLORO-5-FLUORO-3-(HYDROXYMETHYL)PYRIDINE(870063-52-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 870063-52-8(Hazardous Substances Data)

Usage

General Description

2-Chloro-5-fluoro-3-(hydroxymethyl)pyridine is a chemical compound that belongs to the pyridine group. It is a halogenated and fluorinated derivative of pyridine with a hydroxymethyl functional group attached to the third carbon atom. 2-CHLORO-5-FLUORO-3-(HYDROXYMETHYL)PYRIDINE is often used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. Its unique chemical structure and reactivity make it a valuable building block for the production of a wide range of products. Additionally, its halogen and hydroxymethyl groups contribute to its diverse applications in chemical reactions and organic synthesis processes.

InChI:InChI=1/C6H5ClFNO/c7-6-4(3-10)1-5(8)2-9-6/h1-2,10H,3H2

Upstream product

• 847729-27-5 2-chloro-5-fluoronicotinic acid methyl ester 
• 82671-06-5 2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid 
• 38186-88-8 2-chloro-5-fluoronicotinic acid 

Downstream Products

• 1350653-23-4 5-fluoro-3-iodo-1H-pyrazolo[3,4-b]pyridine 
• 851484-95-2 2-chloro-5-fluoropyridine-3-carbaldehyde 

Relevant articles and documents

Preparation method of 5-fluoro-3-iodo-1H-pyrazolo [3, 4-b] pyridine

The invention discloses a preparation method of 5-fluoro-3-iodo-1H-pyrazolo [3, 4-b] pyridine, and belongs to the field of medicinal chemistry. The method specifically comprises the following steps: S1, carrying out reduction reaction on 2-chloro-5-fluoronicotinic acid serving as a starting point to obtain 2-chloro-3-hydroxymethyl-5-fluoropyridine; S2,carrying out oxidation reaction on the 2-chloro-3-hydroxymethyl-5-fluoropyridineto obtain 2-chloro-3-formyl-5-fluoropyridine; S3, enabling that the 2-chloro-3-formyl-5-fluoropyridine is subjected to ring closing through hydrazine hydrate, so that 5-fluoro-1H-pyrazolo [3, 4-b] pyridine is obtained; and S4, carrying out an iodination reaction on the 5-fluoro-1H-pyrazolo [3, 4-b] pyridine, so as to obtain the 5-fluoro-3-iodo-1H-pyrazolo [3, 4-b] pyridine. The four-step reaction of the preparation method does not use strongly corrosive acidic materials, so that the preparation method has the advantages of high safety operability, small damage to equipment and facilities, high safety operability in material storage, transfer and use links, avoidance of diazonium salt reaction for releasing nitrogen in the prior art, high safety controllability, mild reaction conditions, higher safety, simplicity in operation, high yield, and suitability for industrial production.

ARYL-ANILINE AND HETEROARYL-ANILINE COMPOUNDS FOR TREATMENT OF BIRTHMARKS

Provided herein are compounds and pharmaceutical compositions thereof for treating a birthmark in a subject in need thereof, wherein the compound is according to any one of formula (1), (II), (III), (IV), and (V). wherein X1, X2, X3, R1, R2, R2a, R13, R13a, R23, R23a, R23b, R33, R33a, R33b, R43, R43a, R51, R53, R53a, R53b, bond "a", and subscript n are described herein.

HETEROCYCLIC COMPOUNDS WITH AN ROR(GAMMA)T MODULATING ACTIVITY

The present invention relates to a compound that may have an ROR(gamma)t modulating activity and can thus be useful in the treatment of cancer.