870063-60-8

Basic information

• Product Name: 3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE
• Synonyms: (3-FLUOROPYRIDIN-4-YL)METHANOL;3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE;3-Fluoro-4-(hydroxyMethyl...;4-PyridineMethanol, 3-fluoro-;3-fluoro-4-Pyridinemethanol;(3-Fluoro-Pyridin-4-Yl)-Methanol(WX640299)
• CAS NO: 870063-60-8
• Molecular Formula: C₆H₆FNO
• Molecular Weight: 127.117
• Mol File: 870063-60-8.mol
• Article Data: 13

Chemical Properties

• Melting Point: 83-84 °C
• Boiling Point: 220.969°C at 760 mmHg
• Flash Point: 87.439°C
• Appearance: /
• Density: 1.263g/cm³
• Vapor Pressure: 0.063mmHg at 25°C
• Refractive Index: 1.524
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 12.71±0.10(Predicted)
• CAS DataBase Reference: 3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE(870063-60-8)
• EPA Substance Registry System: 3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE(870063-60-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 870063-60-8(Hazardous Substances Data)

Usage

General Description

3-Fluoro-4-(hydroxymethyl)pyridine is a chemical compound that consists of a pyridine ring with a fluorine atom at the 3 position and a hydroxymethyl group at the 4 position. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. The presence of the hydroxymethyl group makes it a versatile building block for the construction of more complex molecules. 3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE is often used in medicinal chemistry and drug discovery research for the development of new therapeutic agents. Its unique structure and reactivity make it a valuable tool in organic synthesis and chemical biology.

InChI:InChI=1/C6H6FNO/c7-6-3-8-2-1-5(6)4-9/h1-3,9H,4H2

Upstream product

• 372-47-4 3-Fluoropyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 1289010-50-9 3-fluoroisonicotinaldehyde 
• 876919-08-3 methyl 3-fluoropyridine-4-carboxylate 
• 40273-47-0 3-fluoropyridine-4-carbaldehyde 
• 393-53-3 3-fluoroisonicotinic acid 

Downstream Products

• 1303972-96-4 (3S,4R)-tert-butyl 4-(aminomethyl)-3-fluoropiperidine-1-carboxylate 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AS PAD INHIBITORS

Heterocyclic compounds of Formula (I), (II), and (III) are described herein along with their polymorphs, stereoisomers, prodrugs, solvates, co-crystals, intermediates, pharmaceutically acceptable salts, and metabolites thereof. The compounds described herein, their polymorphs, stereoisomers, prodrugs, solvates, co-crystals, intermediates, pharmaceutically acceptable salts, and metabolites thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosis, cutaneous lupus erythematosis, ulcerative colitis, cancer, cystic fibrosis, asthma, multiple sclerosis and psoriasis.

FLUOROINDOLE DERIVATIVES AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS

The present invention relates to compound of formula (I), or stereoisomers and pharmaceutically acceptable salts as muscarinic M1 receptor positive allosteric modulators. This invention also relates to methods of making such compounds and pharmaceutical compositions comprising such compounds. The compounds of this invention are useful in the treatment of various disorders that are related to muscarinic M1 receptor.(Formula I) (I)

BICYCLIC AZAHETEROCYCLIC COMPOUNDS AS NR2B NMDA RECEPTOR ANTAGONISTS

Disclosed are chemical entities of Formula (I): wherein R1 and Z are defined herein, as NR2B subtype selective receptor antagonists. Also disclosed are pharmaceutical compositions comprising a chemical entity of Formula (I), and methods of treating various diseases and disorders associated with NR2B antagonism, e.g., diseases and disorders of the CNS, such as depression, by administering a chemical entity of Formula (I).