870300-80-4Relevant articles and documents
tert-butyl (phenylsulfonyl)alkyl-N-hydroxycarbamates: The first class of N-(Boc) nitrone equivalents
Guinchard, Xavier,Vallee, Yannick,Denis, Jean-Noel
, p. 5147 - 5150 (2005)
(Chemical Equation Presented) tert-Butyl (phenylsulfonyl)alkyl-N- hydroxycarbamates 1 have been easily prepared from aldehydes and tert-butyl N-hydroxycarbamate in a methanol-water mixture using sodium benzenesulfinate and formic acid. These sulfones 1 behave as N-(Boc)-protected nitrones 4 in the reaction with organometallics to give N-(Boc)hydroxylamines. Some chemical transformations showing their interest as building blocks in organic synthesis are described.