870526-99-1Relevant articles and documents
Synthesis of desthio prenylcysteine analogs: Sulfur is important for biological activity
Henriksen, Brian S.,Anderson, Jessica L.,Hrycyna, Christine A.,Gibbs, Richard A.
, p. 5080 - 5083 (2007/10/03)
N-Acetyl-S-farnesyl cysteine (AFC) is the minimal synthetic substrate for the enzyme Icmt, which methylates prenylated proteins. The desthio-AFC isostere 2 has been synthesized in racemic form. This analog was not an Icmt substrate, but instead a weak inh