870694-34-1

Basic information

• Product Name: 1-(5-BROMO-2-PYRIDINYL)-1,2-ETHANEDIOL
• Synonyms: 1-(5-BROMO-2-PYRIDINYL)-1,2-ETHANEDIOL;1,2-ETHANEDIOL, 1-(5-BROMO-2-PYRIDINYL)-;1-(5-bromopyridin-2-yl)ethane-1,2-diol
• CAS NO: 870694-34-1
• Molecular Formula: C7H8BrNO2
• Molecular Weight: 218.049
• Mol File: 870694-34-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(5-BROMO-2-PYRIDINYL)-1,2-ETHANEDIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-BROMO-2-PYRIDINYL)-1,2-ETHANEDIOL(870694-34-1)
• EPA Substance Registry System: 1-(5-BROMO-2-PYRIDINYL)-1,2-ETHANEDIOL(870694-34-1)

Safety Data

• Hazardous Substances Data: 870694-34-1(Hazardous Substances Data)

Usage

Description

1-(5-BROMO-2-PYRIDINYL)-1,2-ETHANEDIOL, with the molecular formula C7H7BrNO2, is a chemical compound belonging to the pyridine class and specifically a bromopyridine. This halogenated derivative of pyridine is known for its utility in various chemical reactions and synthesis processes, making it a versatile compound in the fields of pharmaceuticals and agrochemicals. The presence of a hydroxyl group in the molecule endows it with potential enzyme and protein inhibitory properties, which are of significant interest in biochemical and pharmacological research. Furthermore, it has been explored as a building block for the synthesis of other organic compounds.

Uses

Used in Pharmaceutical Applications:
1-(5-BROMO-2-PYRIDINYL)-1,2-ETHANEDIOL is used as an intermediate in the synthesis of pharmaceutical compounds due to its unique chemical structure and reactivity. Its ability to participate in various chemical reactions makes it a valuable component in the development of new drugs.
Used in Agrochemical Applications:
In the agrochemical industry, 1-(5-BROMO-2-PYRIDINYL)-1,2-ETHANEDIOL is used as a starting material for the creation of novel agrochemicals. Its properties allow for the development of compounds with potential applications in pest control and crop protection.
Used in Biochemical Research:
1-(5-BROMO-2-PYRIDINYL)-1,2-ETHANEDIOL is used as a research tool in the field of biochemistry. Its potential as an enzyme and protein inhibitor makes it a valuable asset in studying the mechanisms of various biological processes and the development of targeted therapies.
Used in Organic Synthesis:
As a building block for the synthesis of other organic compounds, 1-(5-BROMO-2-PYRIDINYL)-1,2-ETHANEDIOL is utilized in the development of new chemical entities with diverse applications, ranging from materials science to specialty chemicals.

Upstream product

• 214701-49-2 1-(5-bromopyridin-2-yl)ethanone 
• 97483-77-7 2-Cyano-5-bromopyridine 
• 1260759-84-9 1-(5-bromo-pyridin-2-yl)-2-chloro-ethanone 
• 624-28-2 2,5-dibromopyridine 
• 1427172-16-4 2-(5-bromopyridin-2-yl)-2-oxoethyl acetate 
• 870694-29-4 2-bromo-1-(5-bromopyridin-2-yl)ethanone hydrobromide 
• 870694-43-2 2-bromo-1-(5-bromopyridin-2-yl)ethanone 

Relevant articles and documents

Solubility-driven optimization of (pyridin-3-yl) benzoxazinyl- oxazolidinones leading to a promising antibacterial agent

The solubility-driven structural modification of (pyridin-3-yl) benzoxazinyl-oxazolidinones is described, which resulted in the development of a new series of benzoxazinyl-oxazolidinone analogues with high antibacterial activity against Gram-positive pathogens, including that against linezolid-resistant strains and low hERG inhibition. With regard to structure-activity relationship (SAR) trends among the various substituents on the pyridyl ring, relatively small and nonbasic substituents were preferable to sterically demanding or basic substituents. Oxazolidinone ring substitution on the pyridyl ring generated analogues with antibacterial activity superior to imidazolidinone ring. Solubility was enhanced by the incorporation of polar groups, especially when compounds were converted to their prodrugs. Among the prodrugs, compound 85 exhibited excellent solubility and a good pharmacokinetic profile. In a MRSA systemic infection model, compound 85 displayed an ED 50 = 5.00 mg/kg, a potency that is 2-fold better than that of linezolid.

3- {4- (PYRIDIN-3-YL) PHENYL} -5- (1H-1, 2, 3-TRIAZOL-1-YLMETHYL) -1, 3-OXAZOLIDIN-2-ONES AS ANTIBACTERIAL AGENTS

Compounds of formula (I), as well as pharmaceutically-acceptable salts and pro-drugs thereof, are disclosed wherein R1, R2, R3, and R4 are defined herein. Also disclosed are processes for making compounds of formula (I) as well as methods of using compounds of formula (I) for treating bacterial infections.