870703-61-0

Basic information

• Product Name: 6-(DI-BOC-AMINO)-2-BROMOPYRIDINE
• Synonyms: 6-(Di-Boc-amino)-2-bromopyridine 96%;Di-tert-butyl 6-bromopyridin-2-ylimidodicarbonate
• CAS NO: 870703-61-0
• Molecular Formula: C₁₅H₂₁BrN₂O₄
• Molecular Weight: 373.25
• Product Categories: C9 to C46Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyridines
• Mol File: 870703-61-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 123-127 °C(lit.)
• Boiling Point: 416.6 °C at 760 mmHg
• Flash Point: 205.8 °C
• Appearance: /
• Density: 1.352 g/cm³
• Vapor Pressure: 3.78E-07mmHg at 25°C
• Refractive Index: 1.542
• CAS DataBase Reference: 6-(DI-BOC-AMINO)-2-BROMOPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(DI-BOC-AMINO)-2-BROMOPYRIDINE(870703-61-0)
• EPA Substance Registry System: 6-(DI-BOC-AMINO)-2-BROMOPYRIDINE(870703-61-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 870703-61-0(Hazardous Substances Data)

Usage

Description

6-(Di-Boc-amino)-2-bromopyridine is a chemical compound with the molecular formula C15H19BrN2O4. It is a derivative of pyridine and contains a 2-bromopyridine core with a di-Boc-protected amino group at the 6-position. The di-Boc protecting group consists of two tert-butoxycarbonyl (Boc) groups and serves to protect the amino group from unwanted reactions.

Uses

Used in Organic Synthesis:
6-(Di-Boc-amino)-2-bromopyridine is used as a building block for the synthesis of various biologically active molecules. Its di-Boc-protected amino group allows for selective reactions to occur at other sites on the molecule, making it a valuable reagent in organic synthesis.
Used in Medicinal Chemistry:
6-(Di-Boc-amino)-2-bromopyridine is used as a key intermediate in the preparation of functionalized pyridine derivatives. These derivatives have potential applications in drug discovery and development, as they can be further modified to create new pharmaceutical compounds with specific biological activities.
Used in Drug Discovery and Development:
6-(Di-Boc-amino)-2-bromopyridine has potential applications in drug discovery and development due to its ability to be incorporated into various biologically active molecules. Its unique structure and the presence of the di-Boc protecting group make it a versatile building block for the creation of new pharmaceutical compounds with potential therapeutic benefits.

InChI:InChI=1/C15H21BrN2O4/c1-14(2,3)21-12(19)18(13(20)22-15(4,5)6)11-9-7-8-10(16)17-11/h7-9H,1-6H3

Upstream product

• 19798-81-3 2-Amino-6-bromopyridine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 344331-90-4 tert-butyl 6-bromopyridin-2-ylcarbamate 
• 1446790-79-9 4-(6-(2H-1,2,3-triazol-2-yl)pyridin-2-ylamino)-6-((1R,2S)-2-aminocyclohexylamino)pyridazine-3-carboxamide 
• 1446792-42-2 tert-butyl (1S,2R)-2-(5-(6-(2H-1,2,3-triazol-2-yl)pyridin-2-ylamino)-6-carbamoylpyridazin-3-ylamino)cyclohexylcarbamate 
• 1446790-99-3 4-(6-(1H-pyrazol-1-yl)pyridin-2-ylamino)-6-((1R,2S)-2-aminocyclohexylamino)pyridazine-3-carboxamide 
• 1446793-07-2 tert-butyl (1S,2R)-2-(5-(6-(1H-pyrazol-1-yl)pyridin-2-ylamino)-6-carbamoylpyridazin-3-ylamino)cyclohexylcarbamate 
• 203321-83-9 tert-butyl 6-(hydroxymethyl)-2-pyridinylcarbamate 
• 1187837-10-0 tert-butyl (2-cyclohexylethyl)(6-{[({[3-(methylsulfanyl)phenyl](1-methyl-1H-tetrazol-5-yl)methylene}amino)oxy]methyl}pyridin-2-yl)carbamate 
• 1187836-72-1 N-(2-cyclohexylethyl)-6-{[({[3-(methylsulfanyl)phenyl](1-methyl-1H-tetrazol-5-yl)methylene}amino)oxy]methyl}pyridin-2-amine 
• 1187837-07-5 tert-butyl (2-cyclohexylethyl)[6-(hydroxymethyl)pyridin-2-yl]carbamate 
• 1187837-09-7 tert-butyl [6-(bromomethyl)pyridin-2-yl](2-cyclohexylethyl)carbamate 

Relevant articles and documents

NOVEL NITROGEN-CONTAINING COMPOUND OR SALT THEREOF, OR METAL COMPLEX THEREOF

The present invention provides a compound represented by the formula (1) or a salt thereof, or a complex of the compound or the salt with a metal, in the formula (1), A1 represents a chelate group; R1 represents a hydrogen atom or the like; R2 represents a hydrogen atom or the like; and Z1, Z2, Z3, Z4, and Z5 are the same or different and each represent a nitrogen atom or CR3 or the like wherein R3 represents a hydrogen atom or an optionally substituted C1-6 alkyl group or the like; L1 represents a group represented by the formula (3) wherein R13, R14, R15, and R16 are the same or different and each represent a hydrogen atom or the like; L2 represents an optionally substituted C1-6 alkylene group; and L3 represents an optionally substituted C1-6 alkylene group.

HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS WITH ELECTROPHILIC FUNCTIONALITY

Heteroaryl pyridone and aza-pyridone amide compounds with electrophilic functionality of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk, and for treating cancer and immune disorders such as inflammation mediated by Btk. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

2,6-Diaminopyridine Compounds Suitable For Treating Diseases Associated With Amyloid Or Amyloid-Like Proteins Or For Treating Or Preventing Ocular Diseases Or Conditions Associated With A Pathological Abnormality/Change In The Tissue Of The Visual System

The present invention relates to 2,6-diaminopyridine compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein and of diseases or conditions associated with amyloid-like proteins. The compounds of the present invention can also be used in the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system.