870822-79-0

Basic information

• Product Name: 3-CHLORO-4-(TRIFLUOROMETHOXY)PHENYLBORONIC ACID
• Synonyms: 3-CHLORO-4-(TRIFLUOROMETHOXY)PHENYLBORONIC ACID
• CAS NO: 870822-79-0
• Molecular Formula: C7H5BClF3O3
• Molecular Weight: 240.3720096
• Mol File: 870822-79-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 202-204 °C
• Boiling Point: 295.3±50.0 °C(Predicted)
• Appearance: /
• Density: 1.53±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 7.27±0.10(Predicted)
• CAS DataBase Reference: 3-CHLORO-4-(TRIFLUOROMETHOXY)PHENYLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-4-(TRIFLUOROMETHOXY)PHENYLBORONIC ACID(870822-79-0)
• EPA Substance Registry System: 3-CHLORO-4-(TRIFLUOROMETHOXY)PHENYLBORONIC ACID(870822-79-0)

Safety Data

• Hazardous Substances Data: 870822-79-0(Hazardous Substances Data)

Usage

General Description

3-Chloro-4-(trifluoromethoxy)phenylboronic acid is a chemical compound with the molecular formula C7H5BClF3O3. It is a boronic acid derivative with a phenyl group substituted by chloro and trifluoromethoxy groups. 3-CHLORO-4-(TRIFLUOROMETHOXY)PHENYLBORONIC ACID is commonly used in organic synthesis as a reagent for the Suzuki-Miyaura cross-coupling reaction to form carbon-carbon bonds. It is also used in the pharmaceutical industry for the synthesis of various drug molecules. Additionally, 3-Chloro-4-(trifluoromethoxy)phenylboronic acid has potential applications in materials science, catalysis, and agrochemicals, making it a versatile and valuable chemical compound.

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Relevant articles and documents

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with a defect in glyoxylate metabolism, for example a disease or disorder associated with the enzyme glycolate oxidase (GO) or alterations in oxalate metabolism. Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

2-PYRIDONE COMPOUNDS

A 2-pyridone compound represented by the formula [1]: {wherein in the formula [1], the ring represented by A represents a benzene ring or a pyridine ring, X represents any of the structures represented by the formulas [3] shown below: V represents a single bond or a lower alkylene group, and W represents a single bond, an ether bond or a lower alkylene group (wherein the lower alkylene group may contain an ether bond)}, a tautomer or stereoisomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof is a compound that has an excellent GK activating effect and is useful as a pharmaceutical.

Synthesis and structure-activity relationships of aza- and diazabiphenyl analogues of the antitubercular drug (6 S)-2-nitro-6-{[4-(trifluoromethoxy) benzyl]oxy}-6,7-dihydro-5 H-imidazo[2,1-b][1,3]oxazine (PA-824)

New heterocyclic analogues of the potent biphenyl class derived from antitubercular drug PA-824 were prepared, aiming to improve aqueous solubility but maintain high metabolic stability and efficacy. The strategy involved replacement of one or both phenyl