870971-19-0

Basic information

• Product Name: 3-Amino-6-methoxypyridine-2-carboxylic acid
• Synonyms: 3-Amino-6-Methoxy-2-PyridineCarboxylicAcid;3-Amino-6-methoxypyridine-2-carboxylic acid;3-Amino-6-methoxy-2-pyridine carboxylic acid ,98%;2-Pyridinecarboxylic acid, 3-aMino-6-Methoxy-;3-Amino-6-methoxypicolinic acid
• CAS NO: 870971-19-0
• Molecular Formula: C7H8N2O3
• Molecular Weight: 168.15
• EINECS: 200-589-5
• Mol File: 870971-19-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 1.384
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 3-Amino-6-methoxypyridine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-6-methoxypyridine-2-carboxylic acid(870971-19-0)
• EPA Substance Registry System: 3-Amino-6-methoxypyridine-2-carboxylic acid(870971-19-0)

Safety Data

• Statements: 20/21/22
• Safety Statements: 36/37
• Hazardous Substances Data: 870971-19-0(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow solid

InChI:InChI=1S/C7H8N2O3/c1-12-5-3-2-4(8)6(9-5)7(10)11/h2-3H,8H2,1H3,(H,10,11)

Upstream product

• 67-56-1 methanol 
• 22282-96-8 6-bromo-2-methyl-3-nitro-pyridine 
• 52090-56-9 3-amino-6-methoxy-2-methylpyridine 
• 52090-65-0 N-(6-methoxy-2-methyl-3-pyridyl)acetamide 
• 856835-28-4 3-(acetylamino)-6-methoxypyridine-2-carboxylic acid 

Relevant articles and documents

Selenium-catalyzed intramolecular atom- And redox-economical transformation ofo-nitrotoluenes into anthranilic acids

Anthranilic acids (AAs) are significant basic chemicals used in pharmaceuticals, agrochemicals, dyes, fragrances,etc. Superfluous steps are always involved in obtaining AAs. Herein, we demonstrate a straightforward strategy to transform abundanto-nitrotoluenes into biologically and pharmaceutically significant AAs without any extra reductants, oxidants and protecting groups. Various sensitive groups, such as halogens, sulfide, aldehyde, pyridines, quinolines,etc., can be tolerated in this transformation. A hundred-gram-scale operation is realized efficiently with almost quantitative selenium recycling. Further mechanistic studies and DFT calculations disclosed the proposed atom-exchange processes and the key roles of the selenium species.

Discovery of agonists of cannabinoid receptor 1 with restricted central nervous system penetration aimed for treatment of gastroesophageal reflux disease

Agonists of the cannabinoid receptor 1 (CB1) have been suggested as possible treatments for a range of medical disorders including gastroesophageal reflux disease (GERD). While centrally acting cannabinoid agonists are known to produce psychotropic effects, it has been suggested that the CB1 receptors in the periphery could play a significant role in reducing reflux. A moderately potent and highly lipophilic series of 2-aminobenzamides was identified through focused screening of GPCR libraries. Development of this series focused on improving potency and efficacy at the CB1 receptor, reducing lipophilicity and limiting the central nervous system (CNS) exposure while maintaining good oral absorption. Improvement of the series led to compounds having excellent potency at the CB1 receptor and high levels of agonism, good physical and pharmacokinetic properties, and low penetration into the CNS. A range of compounds demonstrated a dose-dependent inhibition of transient lower esophageal sphincter relaxations in a dog model.

THERAPEUTIC COMPOUNDS: PYRIDINE AS SCAFFOLD

Compounds of formulas I, IA, and IB or IC or pharmaceutically acceptable salts thereof: wherein A, A1, A2, A3, A4, R2, R3, R4 and n are as defined in the specifications well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.