871012-88-3

Basic information

• Product Name: 2-(4-iodophenyl)pyridine
• Synonyms: 2-(4-iodophenyl)pyridine
• CAS NO: 871012-88-3
• Molecular Weight: 281.096
• Mol File: 871012-88-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-(4-iodophenyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-iodophenyl)pyridine(871012-88-3)
• EPA Substance Registry System: 2-(4-iodophenyl)pyridine(871012-88-3)

Safety Data

• Hazardous Substances Data: 871012-88-3(Hazardous Substances Data)

Usage

Molecular Structure

Consists of a pyridine ring with a phenyl group and an iodine atom attached to it.

Usage

Commonly used as a building block in organic synthesis and pharmaceutical research.

Potential

Acts as a key intermediate in the production of various drugs and biologically active molecules.

Application

Used as a reagent in the preparation of heterocyclic compounds and in the development of new materials.

Biological Activities

Investigated for its potential antitumor, anti-inflammatory, and antimicrobial properties, making it an important molecule in medicinal chemistry research.

Upstream product

• 372-48-5 2-fluoropyridine 
• 624-38-4 para-diiodobenzene 
• 1186026-67-4 1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trimethylsilyl)benzene 
• 106-37-6 1.4-dibromobenzene 
• 13329-40-3 4-Iodoacetophenone 
• 109-76-2 Trimethylenediamine 
• 170230-27-0 (4-(pyridin-2-yl)phenyl)boronic acid 
• 589-87-7 1,4-bromoiodobenzene 
• 5122-99-6 4-iodophenylboronic acid 
• 1338250-05-7 dimethyl 4-iodophenylboronate 
• 109-72-8 n-butyllithium 
• 18471-73-3 4-(pyridin-2-yl)aniline 

Downstream Products

• 871012-90-7 2-(4-trimethylsilylethynylphenyl)pyridine 
• 871012-92-9 2-(4-ethynylphenyl)pyridine 
• 1421006-78-1 (E)-2-(4-iodo-2-(2-methylstyryl)phenyl)pyridine 

Relevant articles and documents

Azimuthal Dipolar Rotor Arrays on Surfaces

A set of dipolar molecular rotor compounds was designed, synthesized and adsorbed as self-assembled 2D arrays on Ag(111) surfaces. The title molecules are constructed from three building blocks: (a) 4,8,12-trioxatriangulene (TOTA) platforms that are known to physisorb on metal surfaces such as Au(111) and Ag(111), (b) phenyl groups attached to the central carbon atom that function as pivot joints to reduce the barrier to rotation, (c) pyridine and pyridazine units as small dipolar units on top. Theoretical calculations and scanning tunneling microscopy (STM) investigations hint at the fact that the dipoles of neighboring rotors interact through space through pairs of energetically favorable head-to-tail arrangements.

A Pyridine–Pyridine Cross-Coupling Reaction via Dearomatized Radical Intermediates

A pyridine–pyridine coupling reaction has been developed between pyridyl phosphonium salts and cyanopyridines using B2pin2 as an electron-transfer reagent. Complete regio- and cross-selectivity are observed when forming a range of valuable 2,4′-bipyridines. Phosphonium salts were found to be the only viable radical precursors in this process, and mechanistic studies indicate that the process does not proceed through a Minisci-type coupling involving a pyridyl radical. Instead, a radical–radical coupling process between a boryl phosphonium pyridyl radical and a boryl-stabilized cyanopyridine radical explains the C?C bond-forming step.

Highly Branched Dendrimers

A dendrimer of formula (I): [DENDRON1]x-CORE-[B-[X]b]a (I) wherein: CORE is a metal ion or a group containing a metal ion, or is a non-polymeric organic group; B is a phenyl ring; a is an integer of from 1 to 8;