871115-59-2

Basic information

• Product Name: N-{1-benzyl-3-[(2,2,2-trifluoro-acetylamino)-methyl]-pyrrolidin-3-yl}-2,2,2-trifluoro-acetamide
• Synonyms: N-{1-benzyl-3-[(2,2,2-trifluoro-acetylamino)-methyl]-pyrrolidin-3-yl}-2,2,2-trifluoro-acetamide
• CAS NO: 871115-59-2
• Molecular Weight: 397.32
• Mol File: 871115-59-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-{1-benzyl-3-[(2,2,2-trifluoro-acetylamino)-methyl]-pyrrolidin-3-yl}-2,2,2-trifluoro-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{1-benzyl-3-[(2,2,2-trifluoro-acetylamino)-methyl]-pyrrolidin-3-yl}-2,2,2-trifluoro-acetamide(871115-59-2)
• EPA Substance Registry System: N-{1-benzyl-3-[(2,2,2-trifluoro-acetylamino)-methyl]-pyrrolidin-3-yl}-2,2,2-trifluoro-acetamide(871115-59-2)

Safety Data

• Hazardous Substances Data: 871115-59-2(Hazardous Substances Data)

Upstream product

• 871115-57-0 3-(2,2,2-trifluoro-acetylamino)-3-[(2,2,2-trifluoro-acetylamino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 871115-56-9 3-aminomethyl-3-(2,2,2-trifluoro-acetylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 871115-55-8 3-cyano-3-(2,2,2-trifluoro-acetylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 871115-54-7 tert-butyl 3-amino-3-cyanopyrrolidine-1-carboxylate 
• 100-52-7 benzaldehyde 

Downstream Products

• 871116-13-1 3-aminomethyl-1-benzyl-pyrrolidin-3-ylamine 

Relevant articles and documents

Synthesis and antibacterial evaluation of a novel series of rifabutin-like spirorifamycins

A novel series of spirorifamycins was synthesized and their antibacterial activity evaluated both in vitro and in vivo. This new series of rifamycins shows excellent activity against Staphylococcus aureus that is equivalent to rifabutin. However, some compounds of the series exhibit lower MICs than rifabutin against rifampin-resistant strains of S. aureus. Further, compound 2e exhibits comparable efficacy in vivo in a murine model of S. aureus septicemia model following administration by either oral or parenteral dosing routes.