87143-17-7

Basic information

• Product Name: Benzene, (4-methylenecyclohexyl)-
• CAS NO: 87143-17-7
• Molecular Formula: C13H16
• Molecular Weight: 172.27
• Mol File: 87143-17-7.mol
• Article Data: 40

Chemical Properties

• CAS DataBase Reference: Benzene, (4-methylenecyclohexyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, (4-methylenecyclohexyl)-(87143-17-7)
• EPA Substance Registry System: Benzene, (4-methylenecyclohexyl)-(87143-17-7)

Safety Data

• Hazardous Substances Data: 87143-17-7(Hazardous Substances Data)

Upstream product

• 4894-75-1 1-phenyl-4-cyclohexanone 
• 865-47-4 potassium tert-butylate 
• 1466-74-6 4‐phenylcyclohexan‐1‐carbaldehyde 
• 2065-66-9 methyl-triphenylphosphonium iodide 
• 27200-84-6 methyl triphenylphosphonium bromide 
• 74-88-4 methyl iodide 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 1822-00-0 trimethylsilylmethyllithium 
• 136613-01-9 4-phenylcyclohexanone dimethylacetal 
• 2862-92-2 1-methyl-4-phenylcyclohexan-1-ol 
• 75-24-1 trimethylaluminum 

Downstream Products

• 52092-29-2 (trans)-2-(4-phenylcyclohexyl)acetic acid 
• 148962-93-0 (cis)-2-(4-phenylcyclohexyl)acetic acid 
• 94089-85-7 7-<(2,2,2-trichloroethoxy)sulfonyl>-3-phenyl-7-azaspiro<3.5>-8-nonanone 
• 94089-86-8 3-phenyl-7-azaspiro<3.5>-8-nonanone 
• 1138530-12-7 3-(1-azido-4-phenyl-cyclohexyl)-propionic acid ethyl ester 
• 1138530-13-8 3-(1-azido-4-phenyl-cyclohexyl)-propionic acid ethyl ester 
• 1335135-18-6 (4-(2,2,2-trifluoroethyl)cyclohex-3-enyl)benzene 
• 1354702-93-4 cis-ethyl 3-(1-chloro-4-phenylcyclohexyl)propanoate 
• 1354702-94-5 trans-ethyl 3-(1-chloro-4-phenylcyclohexyl)propanoate 
• 1411702-69-6 8-phenyl-1-oxaspiro[4.5]decan-2-one 
• 1411701-80-8 ethyl 3-(1,2,3,6-tetrahydro-[1,1'-biphenyl]-4-yl)propanoate 
• 1411702-26-5 ethyl 3-(4-phenylcyclohexyl)prop-3-enoate 
• 1411701-46-6 ethyl 3-(1-iodo-4-phenylcyclohexyl)propanoate 
• 1619992-33-4 6-phenylspiro[2.5]oct-1-ene 

Relevant articles and documents

In Situ Preparation of (μ-Chloro)(μ-methylene)bis(cyclopentadienyl)(dimethylaluminum)titanium (Tebbe's Reagent)

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Cobalt-Catalyzed Desymmetric Isomerization of Exocyclic Olefins

Chiral cyclic olefins, 1-methylcyclohexenes, are versatile building blocks for the synthesis of pharmaceuticals and natural products. Despite the prevalence of these structural motifs, the development of efficient synthetic methods remains an unmet challenge. Herein we report a novel desymmetric isomerization of exocyclic olefins using a series of newly designed chiral cobalt catalysts, which enables a straightforward construction of chiral 1-methylcyclohexenes with diversified functionalities. The synthetic utility of this methodology is highlighted by a concise and enantioselective synthesis of a natural product, β-bisabolene. The versatility of the reaction products is further demonstrated by multifarious derivatizations.

Insertion of Alkylidene Carbenes into B-H Bonds

We have developed a protocol for insertion of alkylidene carbenes into the B-H bonds of amine-borane adducts, enabling, for the first time, the construction of C(sp2)-B bonds by means of carbene-insertion reactions. Various acyclic and cyclic alkenyl borane-amine adducts were prepared from readily accessible starting materials in good to high yields and were subsequently subjected to a diverse array of functional group transformations. The unprecedented spiro B-N heterocycles prepared in this study have potential utility as building blocks for the synthesis of pharmaceuticals. Preliminary mechanistic studies suggest that insertion of the alkylidene carbenes into the B-H bonds of the amine-borane adducts proceeds via a concerted process involving a three-membered-ring transition state.