871507-16-3 Usage
Description
(E)-1-(4-((quinolin-2-yl)methoxy)phenyl)-3-(dimethylamino)-2-(pyridin-4-yl)prop-2-en-1-one is a complex organic molecule with a central prop-2-en-1-one group, featuring additional phenyl and pyridin-4-yl groups, as well as a quinolin-2-yl and a dimethylamino group. These structural components contribute to its unique properties, which may hold potential applications in various fields such as pharmaceuticals, materials science, and chemical research. However, further study and testing are necessary to fully comprehend its potential uses and effects.
Uses
Used in Pharmaceutical Applications:
(E)-1-(4-((quinolin-2-yl)methoxy)phenyl)-3-(dimethylamino)-2-(pyridin-4-yl)prop-2-en-1-one is used as a potential active pharmaceutical ingredient for [application reason], given its complex molecular structure and the presence of various functional groups that may interact with biological targets.
Used in Materials Science:
In the field of materials science, (E)-1-(4-((quinolin-2-yl)methoxy)phenyl)-3-(dimethylamino)-2-(pyridin-4-yl)prop-2-en-1-one is used as a component in the development of [specific material or application] due to its [particular property or reason for use].
Used in Chemical Research:
(E)-1-(4-((quinolin-2-yl)methoxy)phenyl)-3-(dimethylamino)-2-(pyridin-4-yl)prop-2-en-1-one serves as a subject of study in chemical research for [specific area of research or reason for study], such as exploring its reactivity, stability, or potential to form new compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 871507-16-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,1,5,0 and 7 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 871507-16:
(8*8)+(7*7)+(6*1)+(5*5)+(4*0)+(3*7)+(2*1)+(1*6)=173
173 % 10 = 3
So 871507-16-3 is a valid CAS Registry Number.
871507-16-3Relevant articles and documents
Radiosynthesis and in vivo evaluation of [11C]MP-10 as a PET probe for imaging PDE10A in rodent and non-human primate brain
Tu, Zhude,Fan, Jinda,Li, Shihong,Jones, Lynne A.,Cui, Jinquan,Padakanti, Prashanth K.,Xu, Jinbin,Zeng, Dexing,Shoghi, Kooresh I.,Perlmutter, Joel S.,MacH, Robert H.
supporting information; experimental part, p. 1666 - 1673 (2011/04/16)
2-((4-(1-[11C]Methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy) methyl)-quinoline (MP-10), a specific PDE10A inhibitor (IC50 = 0.18 nM with 100-fold selectivity over other PDEs), was radiosynthesized by alkylation of the desmethyl precursor with [11C]CH3I, ～45% yield, >92% radiochemical purity, >370 GBq/μmol specific activity at end of bombardment (EOB). Evaluation in Sprague-Dawley rats revealed that [11C]MP-10 had highest brain accumulation in the PDE10A enriched-striatum, the 30 min striatum: cerebellum ratio reached 6.55. MicroPET studies of [11C]MP-10 in monkeys displayed selective uptake in striatum. However, a radiolabeled metabolite capable of penetrating the blood-brain-barrier may limit the clinical utility of [11C]MP-10 as a PDE10A PET tracer.
Heteroaromatic quinoline compounds
-
Page/Page column 24, (2008/06/13)
The invention pertains to heteroaromatic compounds that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors of PDE10. The invention also relates to intermediates for preparation of said compounds; pharmaceutical compositions comprising said compounds; and the use of said compounds in a method for treating certain central nervous system (CNS) or other disorders.
