871700-37-7

Basic information

• Product Name: N-(2-fluoro-4-iodophenyl)-N'-methylurea
• Synonyms: N-(2-fluoro-4-iodophenyl)-N'-methylurea
• CAS NO: 871700-37-7
• Molecular Weight: 294.067
• Mol File: 871700-37-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(2-fluoro-4-iodophenyl)-N'-methylurea(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-fluoro-4-iodophenyl)-N'-methylurea(871700-37-7)
• EPA Substance Registry System: N-(2-fluoro-4-iodophenyl)-N'-methylurea(871700-37-7)

Safety Data

• Hazardous Substances Data: 871700-37-7(Hazardous Substances Data)

Upstream product

• 139072-17-6 4-iodo-2-fluorophenyl isocyanate 
• 74-89-5 methylamine 
• 29632-74-4 2-fluro-4-iodoaniline 
• 530-62-1 1,1'-carbonyldiimidazole 

Downstream Products

• 1258884-52-4 2-fluoro-4-iodo-N-((methylimino)methylene)aniline 
• 1359760-19-2 2-[1-(4-bromo-2-fluorobenzyl)-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]benzonitrile 
• 1359761-10-6 2-(3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)benzonitrile 
• 871700-17-3 trametinib 

Relevant articles and documents

SUBSTITUTED PYRIDINONE COMPOUNDS AS MEK INHIBITORS

The invention provides novel substituted heterocyclic compounds represented by Formula I and Formula II, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of MEK and are useful in the treatment of inflammatory diseases, cancer and other hyperproliferative diseases. The invention further provides a method of treatment for inflammatory diseases, cancer and other hyperproliferative diseases in mammals, especially humans.

HETEROCYCLIC COMPOUNDS AS MEK INHIBITORS

The invention provides novel substituted heterocyclic compounds represented by Formula I and Formula II, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tauntomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of MEK and are useful in the treatment of inflammatory diseases, cancer and other hyperproliferative diseases. The invention further provides a method of treatment for inflammatory diseases, cancer and other hyperproliferative diseases in mammals, especially humans

5-AMINO-2,4,7-TRIOXO-3,4,7,8-TETRAHYDRO-2H-PYRIDO’2,3-D! PYRIMIDINE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF CANCER

The present invention relates to a pyrimidine compound represented by the following formula [I] wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, and a pharmaceutical agent for the prophylaxis or treatment of a disease caused by undesirable cell proliferation, particularly an antitumor agent, which contains such compound. The compound of the present invention has superior undesirable cell proliferation suppressing action, particularly, an antitumor action, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, antirheumatoid agent and the like. In addition, by the combined use with other antitumor agent such as alkylating agent, metabolism antagonist and the like, it can be a more effective antitumor agent.