87179-80-4 Usage
Piperidinone derivative
1-benzyl-5-hydroxypiperidin-2-one is a derivative of piperidinone, which is a heterocyclic organic compound with a six-membered ring structure.
Benzyl group attached to nitrogen
The compound has a benzyl group (a phenyl group connected to a methyl group) attached to the nitrogen atom of the piperidinone ring.
Hydroxyl group at the 5-position
The compound has a hydroxyl group (-OH) attached to the 5-position of the piperidinone ring, which refers to the position of the hydroxyl group on the ring.
Pharmacological applications
1-benzyl-5-hydroxypiperidin-2-one has been studied for its potential pharmacological applications, including as a precursor for the synthesis of various pharmaceuticals.
Dopamine D1 receptor antagonist
The compound has been investigated for its potential as a dopamine D1 receptor antagonist, which means it may be able to block or reduce the activity of dopamine D1 receptors in the brain.
Treatment of addiction and neurological disorders
1-benzyl-5-hydroxypiperidin-2-one has been studied as a potential drug for the treatment of addiction and neurological disorders due to its potential dopamine D1 receptor antagonist activity.
Synthesis of pharmaceutical intermediates and organic compounds
The compound has been used in the synthesis of pharmaceutical intermediates and organic compounds due to its unique structure and reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 87179-80-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,7,1,7 and 9 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 87179-80:
(7*8)+(6*7)+(5*1)+(4*7)+(3*9)+(2*8)+(1*0)=174
174 % 10 = 4
So 87179-80-4 is a valid CAS Registry Number.
87179-80-4Relevant articles and documents
Oxyamination of Unactivated Alkenes with Electron-Rich Amines and Acids via a Catalytic Triiodide Intermediate
Wu, Fan,Ariyarathna, Jeewani P.,Alom, Nur-E,Kaur, Navdeep,Li, Wei
supporting information, p. 884 - 890 (2020/01/31)
An aerobic catalytic oxidation process is described for the olefin oxyamination using acids and primary amines as the sources of O and N. Our mechanistic findings point to the formation of triiodide as a critical catalytic intermediate to account for the
Chemical and enzymatic synthesis of 2-(2-carbamoylethyl)- and 2-(2-carboxyethyl)aziridines and their conversion into δ-lactams and γ-lactones
Vervisch, Karel,D'Hooghe, Matthias,Rutjes, Floris P. J. T.,De Kimpe, Norbert
scheme or table, p. 106 - 109 (2012/02/14)
Treatment of 1-arylmethyl-2-(2-cyanoethyl)aziridines with a nitrile hydratase afforded the corresponding 2-(2-carbamoylethyl)aziridines, which underwent rearrangement into 5-hydroxypiperidin-2-ones upon heating under microwave irradiation. In addition, tr
Regio- and diastereocontrolled C-H insertion of chiral γ- and δ-lactam diazoacetates. Application to the asymmetric synthesis of (8S,8aS)-8-hydroxyindolizidine
Fan, Gao-Jun,Wang, Zhongyi,Wee, Andrew G. H.
, p. 3732 - 3734 (2007/10/03)
γ- and δ-Lactam diazoacetates undergo efficient intramolecular C-H insertion catalyzed by Rh2(MPPIM)4 with excellent regioselectivity and cis-diastereoselectivity to provide synthetically useful bicyclic lactam lactones. The Royal So
