87218-34-6Relevant articles and documents
Chiral Lactols, IV. Selectivities in Acetal Formation Reactions of Enantiomerically Pure Lactols using Octahydro-8,9,9-trimethyl-5,8-methano-2H-1-benzopyran-2-ol as a Model
Noe, Christian R.,Knollmueller, Max,Wagner, Ernst,Voellenkle, Horst
, p. 1733 - 1745 (2007/10/02)
A synthesis of lactol 1 is described and its application as a reagent for the resolution of racemates is demonstrated in several examples.By means of X-ray and conformation analysis a general rule is given, which allows to predict the absolute configuration of acyclic alkyl-aryl-carbinols from the course of acetal formation between an enantiomerically pure lactol and the racemic alcohol.