872428-47-2Relevant articles and documents
A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtype 5 and blocks the effects of multiple allosteric modulators
Rodriguez, Alice L.,Nong, Yi,Sekaran, Nishant K.,Alagille, David,Tamagnan, Gilles D.,Conn, P. Jeffrey
, p. 1793 - 1802 (2005)
The metabotropic glutamate receptor subtype 5 (mGlu5) activates calcium mobilization via binding of glutamate, the major excitatory neurotransmitter in the central nervous system. Allosteric modulation of the receptor has recently emerged as a promising a
