87248-50-8 Usage
Description
(+)-NOE'S REAGENT, also known as (+)-Noe-lactol dimer, is a chiral compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals and organic compounds. It possesses unique structural features that enable it to participate in asymmetric reactions, making it a valuable building block in organic synthesis.
Source:
(+)-NOE'S REAGENT is typically derived from natural sources or synthesized through chemical reactions.
Production Methods:
The production of (+)-NOE'S REAGENT involves various chemical synthesis routes, including asymmetric reactions and enzymatic processes, to ensure the desired chiral purity and selectivity.
Uses
Used in Pharmaceutical Industry:
(+)-NOE'S REAGENT is used as a key intermediate for the synthesis of axially chiral isoquinoline derivatives, which are important in the development of new pharmaceuticals with potential therapeutic applications.
Used in Organic Synthesis:
(+)-NOE'S REAGENT is used as a chiral building block for the preparation of various organic compounds, including natural products and biologically active molecules, due to its unique structural features and reactivity.
Used in Halofuginone Lactate Production:
(+)-NOE'S REAGENT is used as a starting material for the synthesis of Halofuginone lactate, a pharmaceutical compound with applications in veterinary medicine and other therapeutic areas. Its use in this context highlights its versatility and importance in the synthesis of diverse pharmaceutical agents.
Check Digit Verification of cas no
The CAS Registry Mumber 87248-50-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,7,2,4 and 8 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 87248-50:
(7*8)+(6*7)+(5*2)+(4*4)+(3*8)+(2*5)+(1*0)=158
158 % 10 = 8
So 87248-50-8 is a valid CAS Registry Number.
87248-50-8Relevant articles and documents
Stereoelektronische Effekte und chirale Erkennung: Ein natuerliches Verwandtschaftssystem chiraler Verbindungen basierend auf Selektivitaeten bei der Acetalbildung
Noe, Christian R.,Knollmueller, Max,Goestl, Georg,Oberhauser, Berndt,Voellenkle, Horst
, p. 467 - 470 (2007/10/02)
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Chiral Lactols, II. Racemate Separation and Enantioselective Acetalisation with the 2,3,3a,4,5,6,7,7a-Octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl Protective Group
Noe, Christian R.
, p. 1591 - 1606 (2007/10/02)
A simple method for the resolution of the chiral alcohols, cyanohydrins, thiols and amines rac-2a - f by the reaction with the chiral protective group 1a ( or 1b, respectively) is described.The diastereomeric derivatives 3a - f and 4a - f are separated by column chromatography or crystallisation.Subsequent methanolysis or hydrolysis, respectively, yields the enantiomers and the recovered protective group.With rac-2a - c preferential acetalisation of the (R)-enantiomers was observed.This phenomenon was investigated by modification of the protective group.Considerations on conformations of 3a point to an important role of the anomeric and exo-anomeric effect in this enantioselective reaction.
