872509-58-5Relevant articles and documents
USES OF SALT-INDUCIBLE KINASE (SIK) INHIBITORS
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Paragraph 00403; 00405, (2016/04/20)
The present disclosure provides methods of treating and/or preventing inflammatory bowel disease (IBD) and graft-versus-host disease (GVHD) using salt-inducible kinase (SIK) inhibitors, such as macrocyclic SIK inhibitors of Formula (I), imidazolyl SIK inh
PYRIMIDINE UREA DERIVATIVES AS KINASE INHIBITORS
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Page/Page column 160-161; 229, (2008/06/13)
The invention relates to compounds of formula (I) wherein the substituents X1, R1, R2, R3 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, and a method for the treatment of such a disease.