872619-43-7Relevant articles and documents
PYRROLOPYRIMIDINE ITK INHIBITORS
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Paragraph 0677; 0678; 0679, (2020/02/27)
Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structures of Formulas (I)-(IV): wherein the R groups, m, n, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.
Synthetic method of 5-bromo-7-azaindole
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, (2019/01/08)
The invention discloses a synthetic method of 5-bromo-7-azaindole. According to the synthetic method, 2, 5-dibromo-2-aminopyridine and 3, 3-diethoxy methyl propionate are subjected to synthesis so asto obtain (E)-3-((3, 5-dibromopyridine-2-yl)imino)methyl propionate; and (E)-3-((3, 5-dibromopyridine-2-yl)imino)methyl propionate is subjected to synthesis so as to obtain 5-bromo-1H-pyrrole [2, 3-b] pyrimidine-3-methyl carboxylate; and 5-bromo-1H-pyrrole [2, 3-b] pyrimidine-3-methyl carboxylate is subjected to synthesis so as to obtain 5-bromo-7-azaindole. Reaction steps are few; operation is convenient; reaction steps are high in yield; industrialized production can be realized; quintal grade production can be realized; and relatively high product yield is ensured.
NEW DERIVATIVES OF 5-ARYL-1H-PYRROLO [2, 3B] PYRIDINE-3-CARBOXAMIDE OR 5-ARYL-1H-PYRROLO [2, 3B] PYRIDINE-3-CARBOXYLIC ACID
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Page/Page column 21-22, (2008/06/13)
The present invention relates to new compounds of formula I as a free base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, a process for their preparation and new intermediates used therein, pharmaceutical formulations containin