87281-43-4

Basic information

• Product Name: 1-Indolizinecarboxylic acid, 5,6,7,8-tetrahydro-, methyl ester
• Synonyms: 5,6,7,8-Tetrahydro-indolizine-1-carboxylic acid methyl ester;methyl 5,6,7,8-tetrahydro-1-indolizinecarboxylate;methyl 5,6,7,8-tetrahydroindolizine-1-carboxylate;5,6,7,8-tetrahydro-1-methoxycarbonylindolizine
• CAS NO: 87281-43-4
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• Mol File: 87281-43-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 313.7±30.0 °C(Predicted)
• Density: 1.19±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 1-Indolizinecarboxylic acid, 5,6,7,8-tetrahydro-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Indolizinecarboxylic acid, 5,6,7,8-tetrahydro-, methyl ester(87281-43-4)
• EPA Substance Registry System: 1-Indolizinecarboxylic acid, 5,6,7,8-tetrahydro-, methyl ester(87281-43-4)

Safety Data

• Hazardous Substances Data: 87281-43-4(Hazardous Substances Data)

Usage

Molecular Structure

A heterocyclic compound containing an indolizine ring with a methyl ester group.

Use in Pharmaceutical Industry

Potential therapeutic properties for the development of novel drugs and therapeutic agents.

Unique Structure

The presence of the indolizine ring and methyl ester group contributes to its potential biological activities.

Improved Solubility

Methyl ester form enhances solubility compared to the parent compound.

Bioavailability

Methyl ester form increases the bioavailability of the compound, making it more easily absorbed by the body.

Potential for Further Research

Promising candidate for investigation and research in drug discovery and development.

Upstream product

• 50-00-0 formaldehyd 
• 922-67-8 propynoic acid methyl ester 
• 4043-87-2 pipecolic Acid 
• 1723-00-8 (R)-(+)-pipecolic acid 
• 54966-20-0 rac-1-formylpiperidine-2-carboxylic acid 
• 920-46-7 Methacryloyl chloride 
• 80-63-7 methyl 2-chloroacrylate 
• 87281-40-1 1-Trimethylsilanylmethyl-piperidine-2-thione 

Downstream Products

• 1448525-91-4 N-(4-hydroxyphenyl)-3-{6-[((3S)-3-(4-morpholinylmethyl)-3,4-dihydro-2(1H)-isoquinolinyl)carbonyl]-1,3-benzodioxol-5-yl}-N-phenyl-5,6,7,8-tetrahydro-1-indolizine carboxamide hydrochloride 

Relevant articles and documents

X=Y-ZH Systems as Potential 1,3-Dipoles. Part 42. Decarboxylative Three Carbon Ring Expansion of Cyclic Secondary α-Amino Acids via Azomethine Ylide Formation.

Cyclic 5- and 6-membered secondary α-amino acids react with formaldehyde and acetylenic dipolarophiles via azomethine ylide formation, cycloaddition and subsequent ring expansion to give 8- and 9-membered rings respectively.Ring expansion occurs by reaction of the bridgehead nitrogen of the initial bicyclic cycloadduct with a further molecule of dipolarophile to give a zwitterion which triggers the ring expansion.Dynamic p.m.r. studies show that ring inversion between pairs of mirror image conformations of the medium ring products are occuring with inversion barriers of 13-14.6 kcal/mol.

HEPATITIS B CAPSID ASSEMBLY MODULATORS

Described herein are hepatitis B capsid assembly modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.

New indolizine compound, preparation method thereof and pharmaceutical compositions containing them (by machine translation)

The invention of the formula (I) compound, Wherein R a, R b, R c, R d, T, R 3, R 4, R 5, X, Y and Het as defined in the description. The invention also relates to a medicament containing the above-mentioned compounds. (by machine translation)