872882-97-8

Basic information

• Product Name: 3-(4-Bromophenyl)-3-methyloxetane
• Synonyms: 3-(4-Bromophenyl)-3-methyloxetane
• CAS NO: 872882-97-8
• Molecular Formula: C₁₀H₁₁BrO
• Molecular Weight: 227.09774
• Mol File: 872882-97-8.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-Bromophenyl)-3-methyloxetane(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Bromophenyl)-3-methyloxetane(872882-97-8)
• EPA Substance Registry System: 3-(4-Bromophenyl)-3-methyloxetane(872882-97-8)

Safety Data

• Hazardous Substances Data: 872882-97-8(Hazardous Substances Data)

Usage

Description

3-(4-Bromophenyl)-3-methyloxetane is a chemical compound belonging to the oxetane family, characterized by a white solid appearance and a molecular formula of C9H9BrO. It features a 4-bromophenyl group attached to a 3-methyl oxetane ring, providing it with unique structural and reactive properties that are highly valuable in organic synthesis.

Uses

Used in Pharmaceutical Industry:
3-(4-Bromophenyl)-3-methyloxetane is used as a building block in organic synthesis for the development of pharmaceuticals. Its unique structure and reactivity contribute to the creation of complex organic molecules, which are essential in designing and producing new drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 3-(4-Bromophenyl)-3-methyloxetane serves as a key component in the synthesis of various agrochemicals. Its role in building complex molecules aids in the development of effective products for agricultural applications.
Used in Research and Development Laboratories:
3-(4-Bromophenyl)-3-methyloxetane is utilized as a reagent in research and development laboratories. It plays a crucial role in the synthesis of a wide range of substances, supporting scientific advancements and innovation in organic chemistry.
Overall, 3-(4-Bromophenyl)-3-methyloxetane holds an essential position in the field of organic chemistry, with its diverse applications spanning across multiple industries, including pharmaceuticals, agrochemicals, and research and development.

Upstream product

• 53578-00-0 2-(4-Bromophenyl)-2,2-dimethoxyethane 
• 99-90-1 para-bromoacetophenone 
• 80909-78-0 p-bromo-α-methylstyrene oxide 
• 10242-62-3 3-methyleneoxetane 
• 106-37-6 1.4-dibromobenzene 
• 41841-16-1 (4-bromo-phenyl)-acetic acid methyl ester 
• 149506-35-4 2-(4-bromophenyl)-malonic acid dimethyl ester 
• 93139-85-6 2-(4-bromophenyl)malonic acid diethyl ester 
• 872882-98-9 diethyl 2-(4-bromophenyl)-2-methylmalonate 
• 14062-25-0 Ethyl 4-bromophenylacetate 
• 66810-01-3 2-(4-bromophenyl)-2-methylpropane-1,3-diol 
• 603-35-0 triphenylphosphine 

Downstream Products

• 1431616-42-0 (4-(3-methyloxetan-3-yl)phenyl)boronic acid 
• 1431616-23-7 6-(4-(3-methyloxetan-3-yl)phenyl)nicotinonitrile 
• 1315567-78-2 4-(3-methyloxetan-3-yl)benzoic acid 
• 1262049-69-3 (5R,8S,11R,13S,14S,17S)-5',5',13-trimethyl-11-[4-(3-methyloxetan-3-yl)phenyl]-17-(pentafluoroethyl)-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxane]-5,17(4H)-diol 

Relevant articles and documents

Chemical space exploration of oxetanes

This paper focuses on new derivatives bearing an oxetane group to extend accessible chemical space for further identification of kinase inhibitors. The ability to modulate kinase activity represents an important therapeutic strategy for the treatment of h

Iron-Nickel Dual-Catalysis: A New Engine for Olefin Functionalization and the Formation of Quaternary Centers

Alkene hydroarylation forms carbon-carbon bonds between two foundational building blocks of organic chemistry: olefins and aromatic rings. In the absence of electronic bias or directing groups, only the Friedel-Crafts reaction allows arenes to engage alkenes with Markovnikov selectivity to generate quaternary carbons. However, the intermediacy of carbocations precludes the use of electron-deficient arenes, including Lewis basic heterocycles. Here we report a highly Markovnikov-selective, dual-catalytic olefin hydroarylation that tolerates arenes and heteroarenes of any electronic character. Hydrogen atom transfer controls the formation of branched products and arene halogenation specifies attachment points on the aromatic ring. Mono-, di-, tri-, and tetra-substituted alkenes yield Markovnikov products including quaternary carbons within nonstrained rings.

Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies

We report here the discovery and pharmacological characterization of N-(1-benzyl-1H-pyrazol-3-yl)-2-phenylacetamide derivatives as potent, selective, brain-penetrating T-type calcium channel blockers. Optimization focused mainly on solubility, brain penetration, and the search for an aminopyrazole metabolite that would be negative in an Ames test. This resulted in the preparation and complete characterization of compound 66b (ACT-709478), which has been selected as a clinical candidate.