87307-84-4

Basic information

• Product Name: ethyl 3-<4-(2-hydroxy-3-methoxyphenyl)pyridin-3-yl>propanoate
• Synonyms: ethyl 3-<4-(2-hydroxy-3-methoxyphenyl)pyridin-3-yl>propanoate
• CAS NO: 87307-84-4
• Molecular Weight: 301.342
• Mol File: 87307-84-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl 3-<4-(2-hydroxy-3-methoxyphenyl)pyridin-3-yl>propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-<4-(2-hydroxy-3-methoxyphenyl)pyridin-3-yl>propanoate(87307-84-4)
• EPA Substance Registry System: ethyl 3-<4-(2-hydroxy-3-methoxyphenyl)pyridin-3-yl>propanoate(87307-84-4)

Safety Data

• Hazardous Substances Data: 87307-84-4(Hazardous Substances Data)

Upstream product

• 1609250-81-8 ethyl 3-(4-(2-hydroxy-3-methoxyphenyl)pyridin-3-yl)propanoate oxalate 
• 87307-80-0 2-(2-(benzyloxy)-3-methoxyphenyl)propan-2-ol 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 87307-77-5 1-<3-methoxy-2-(phenylmethoxy)phenyl>ethanone 
• 87307-78-6 1-<3-methoxy-2-(phenylmethoxy)phenyl>ethanol 
• 2011-06-5 2-benzyloxy-3-methoxybenzaldehyde 
• 59607-99-7 ethyl (E)-3-(pyridin-3-yl)acrylate 
• 87307-89-9 1-Ethoxycarbonyl-3-(2-ethoxycarbonyl-ethyl)-pyridinium; chloride 
• 87307-92-4 1-Ethoxycarbonyl-3-((E)-2-ethoxycarbonyl-vinyl)-pyridinium; chloride 
• 87307-90-2 3-(2-Ethoxycarbonyl-ethyl)-4-(2-ethoxymethoxy-3-methoxy-phenyl)-4H-pyridine-1-carboxylic acid ethyl ester 
• 87307-91-3 ethyl 1,4-dihydro-4-<2-(ethoxymethoxy)-3-methoxyphenyl>-3-(3-ethoxy-3-oxopropenyl)pyridine-1-carboxylate 
• 87307-93-5 ethyl 3-<4-<2-(ethoxymethoxy)-3-methoxyphenyl>pyridin-3-yl>propenoate 
• 64107-54-6 3-pyridin-3-yl-propionic acid ethyl ester 
• 1126-74-5 3-(pyridin-3-yl)acrylic acid 

Downstream Products

• 87307-96-8 4-<2-(2-ethoxy-2-oxoethoxy)3-3-methoxyphenyl>-1-methyl-3-(3-oxo-3-ethoxypropyl)pyridinium iodide 

Relevant articles and documents

Synthesis of enantiopure 10-nornaltrexones in the search for toll-like receptor 4 antagonists and opioid ligands

10-Nornaltrexones (3-(cyclopropylmethyl)-4a,9-dihydroxy-2,3,4,4a,5,6- hexahydro-1H-benzofuro[3,2-e]isoquinolin-7(7aH)-one, 1) have been underexploited in the search for better opioid ligands, and their enantiomers have been unexplored. The synthesis of tr

Synthesis of 3-Methyl-5,6-dihydro-3H-benzofuroisoquinolin-7(7aH)-ones

The coupling of 2-(alkoxymethoxy)phenylcopper derivatives with the salt of ethyl chloroformate and ethyl 3-(pyridin-3-yl)propenoate was found to be an efficient method for the preparation of 4-(2-hydroxyphenyl)pyridines 13 substituted at C-3 with a propanoate side chain.N-Methylation and O-alkylation with ethyl bromoacetate gave salts 3 which when treated with base underwent an intramolecular enolate addition to the pyridinium nucleus to produce spiro 4.Prolonged base treatment of 4 yielded ethyl 3-methyl-7-hydroxy-5,7a-dihydro-3H-benzofuroisoquinoline-6-carboxylates 5 by a Dieckmann reaction.Reduction of 5 led to predominately trans-3-methylhexahydro-1H-benzofuroisoquinolin-7(7aH)-ones, while reduction of 4 and then Dieckmann cyclization yielded mainly the cis isomers.