873298-16-9

Basic information

• Product Name: (1R,2S,3R,5S)-3-Benzyloxy-2-benzyloxymethyl-6-oxa-bicyclo[3.1.0]hexane
• Synonyms: (1R,2S,3R,5S)-3-Benzyloxy-2-benzyloxymethyl-6-oxa-bicyclo[3.1.0]hexane
• CAS NO: 873298-16-9
• Molecular Weight: 310.393
• Mol File: 873298-16-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,2S,3R,5S)-3-Benzyloxy-2-benzyloxymethyl-6-oxa-bicyclo[3.1.0]hexane(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S,3R,5S)-3-Benzyloxy-2-benzyloxymethyl-6-oxa-bicyclo[3.1.0]hexane(873298-16-9)
• EPA Substance Registry System: (1R,2S,3R,5S)-3-Benzyloxy-2-benzyloxymethyl-6-oxa-bicyclo[3.1.0]hexane(873298-16-9)

Safety Data

• Hazardous Substances Data: 873298-16-9(Hazardous Substances Data)

Upstream product

• 4984-82-1 sodium cyclopentadienylide 
• 188399-48-6 (1R,2S)-2-((benzyloxy)methyl)cyclopent-3-en-1-ol 
• 39939-07-6 5-(benzyloxymethyl)cyclopentadiene 
• 3587-60-8 Benzyloxymethyl chloride 
• 100-39-0 benzyl bromide 
• 701278-59-3 (1R,2S,3R,5S)-2-((benzyloxy)methyl)-6-oxabicyclo[3.1.0]hexan-3-ol 

Downstream Products

• 1354695-79-6 [6-Benzyloxy-9-((1R,3S,4R)-4-benzyloxy-3-benzyloxymethyl-2-methylene-cyclopentyl)-9H-purin-2-yl]-[(4-methoxy-phenyl)-diphenyl-methyl]-amine 
• 670275-98-6 (6'aS,7'S,8'R,9'aR)-N-(8'-benzyloxy-7'-benzyloxymethyl-7',8',9',9'a-tetrahydro-6'aH-cyclopenta[4,5]oxazolo[3,2-e]purin-4'-yl)-2-(4-tert-butylphenoxy)acetamide 
• 670275-97-5 (6aS,7S,8R,9aR)-8-benzyloxy-7-benzyloxymethyl-7,8,9,9a-tetrahydro-6aH-cyclopenta[4,5]oxazolo[3,2-e]purin-4-amine 
• 263764-15-4 (5aR,7R,8S,8aS)-7-benzyloxy-8-benzyloxymethyl-5a,7,8,8a-tetrahydro-2H,6H-cyclopenta[4,5]oxazolo[3,2-c]pyrimidine-2,4(3H)-dione 
• 869749-13-3 (5aR,7R,8S,8aS)-7-benzyloxy-8-benzyloxymethyl-5a,7,8,8a-tetrahydro-2H,6H-cyclopenta[4,5]oxazolo[3,2-a]pyrimidine-2-one 
• 263764-12-1 (1'R,2'R,3'R,4'R)-9-(4-benzyloxy-3-benzyloxymethyl-2-hydroxycyclopentyl)adenine 

Relevant articles and documents

BMS-200475, a novel carbocyclic 2'-deoxyguanosine analog with potent and selective anti-hepatitis B virus activity in vitro

BMS-200475, a never carbocyclic analog of 2'-deoxyguanosine, is a potent inhibitor of hepatitis B virus in vitro (ED50 = 3 nM) with relatively low cytotoxicity (CC50 = 21-120 μM). A practical 10-step asymmetric synthesis was developed affording BMS-200475 in 18% overall chemical yield and > 99% optical purity. The enantiomer of BMS-200475 as well as the adenine, thymine, and iodouracil analogs are much less active.