873305-35-2

Basic information

• Product Name: AIM-100
• Synonyms: AIM-100;5,6-Diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]furo[2,3-d]pyrimidin-4-amine
• CAS NO: 873305-35-2
• Molecular Formula: C23H21N3O2
• Molecular Weight: 371.43174
• Product Categories: API
• Mol File: 873305-35-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 552.9±50.0 °C(Predicted)
• Appearance: /
• Density: 1.243±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility: insoluble in H2O; ≥35.8 mg/mL in EtOH with gentle warming; ≥36 mg/mL in DMSO with gentle warming
• PKA: 4.62±0.40(Predicted)
• CAS DataBase Reference: AIM-100(CAS DataBase Reference)
• NIST Chemistry Reference: AIM-100(873305-35-2)
• EPA Substance Registry System: AIM-100(873305-35-2)

Safety Data

• Hazardous Substances Data: 873305-35-2(Hazardous Substances Data)

Usage

Uses

AIM-100 modulates ligand-independent AR activity and inhibits prostate cell growth.

Biological Activity

aim-100 is a small inhibitor of ack1 tyrosine kinase with ic50 value of 24 nm [1].aim-100 mimicked atp and inhibited the activity of ack1 significantly and specifically. it showed no inhibition activity for the other 30 kinases including pi3-kinase and akt, and showed a five-fold higher ic50 value for lck. in mef cells treated with egf, aim-100 caused a remarkable decrease of the activation of ack1. in the human prostate cancer cells lncap and lapc4, aim-100 treatment resulted in an increase of g0/g1 cell phase and subsequent cell growth suppression. these effects of aim-100 also exerted in the pancreatic cancer cells. aim-100 induced apoptosis in panc-1 cells at concentration of 10 μm. moreover, aim-100 inhibited cell growth with gi50 values of 7 to 8 μm in cd-18, panc-1, ov90, mcf-7 and mda-mb-468 cancer cells [1, 2].

references

1. mahajan k, challa s, coppola d, et al. effect of ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity. the prostate, 2010, 70(12): 1274-1285. 2. mahajan k, coppola d, chen y, et al. ack1 tyrosine kinase activation correlates with pancreatic cancer progression. the american journal of pathology, 2012, 180(4): 1386-1393.

Upstream product

• 107833-28-3 N-(3-cyano-4,5-diphenylfuran-2-yl)formamide 
• 5503-73-1 2-amino-3-cyano-4,5-diphenylfuran 
• 65148-07-4 4-chloro-5,6-diphenylfuro[2,3-d]pyrimidine 
• 4795-29-3 S-tetrahydrofurfurylamine 
• 873306-32-2 4-bromo-5,6-diphenyl-furo[2,3-d]pyrimidine 

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