87344-06-7 Usage
Description
Amtolmetin guacil is an orally active non-steroidal antiinflammatory drug (NSAID)
introduced for the treatment of osteoarthritis, rheumatoid arthritis and post-operative pain.
Amtolmetin guacil is reported to elicit a more rapid and improved analgesic action than other
agents such as paracetamol. In models of adjuvant arthritis and rheumatic diseases,
amtolmetin guacil is more efficacious than existing drugs such as naproxen, indomethacin and
piroxicam. As a non-acidic prodrug of tolmetin, it has similar in vivo activity to the parent but
with minor ulcerogenic action, lower acute toxicity, and excellent biological and gastric
tolerability.
Originator
Sigma Tau (Italy)
Uses
Analgesic; anti-inflammatory used in the treatment of rheumatoid arthritis,
Brand name
Artromed
Check Digit Verification of cas no
The CAS Registry Mumber 87344-06-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,7,3,4 and 4 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 87344-06:
(7*8)+(6*7)+(5*3)+(4*4)+(3*4)+(2*0)+(1*6)=147
147 % 10 = 7
So 87344-06-7 is a valid CAS Registry Number.
InChI:InChI=1/C24H24N2O5/c1-16-8-10-17(11-9-16)24(29)19-13-12-18(26(19)2)14-22(27)25-15-23(28)31-21-7-5-4-6-20(21)30-3/h4-13H,14-15H2,1-3H3,(H,25,27)
87344-06-7Relevant articles and documents
Synthesis and process optimization of amtolmetin: An antiinflammatory agent
Reddy, Lekkala Amarnath,Chakraborty, Saurya,Swapna, Rodda,Bhalerao, Dinesh,Malakondaiah, Golla China,Ravikumar, Mylavarapu,Kumar, Abhijeet,Reddy, Gade Srinivas,Naram, Jyothirmayi,Dwivedi, Namrata,Roy, Arnab,Himabindu, Vurimidi,Babu, Bangaru,Bhattacharya, Apurba,Bandichhor, Rakeshwar
experimental part, p. 362 - 368 (2011/03/21)
Efforts toward the synthesis and process optimization of amtolmetin guacil 1 are described. High-yielding electrophilic substitution followed by Wolf-Kishner reduction are the key features in the novel synthesis of tolmetin 2 which is an advanced intermediate of 1.
