87363-79-9

Basic information

• Product Name: Boc-(L)-Ala-Δbut-OMe
• Synonyms: Boc-(L)-Ala-Δbut-OMe
• CAS NO: 87363-79-9
• Molecular Weight: 362.426
• Mol File: 87363-79-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Boc-(L)-Ala-Δbut-OMe(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-(L)-Ala-Δbut-OMe(87363-79-9)
• EPA Substance Registry System: Boc-(L)-Ala-Δbut-OMe(87363-79-9)

Safety Data

• Hazardous Substances Data: 87363-79-9(Hazardous Substances Data)

Upstream product

• 500220-28-0 Boc-L-phenylalanine-L-threonine methyl ester 
• 73763-45-8 N-Boc-L-Phe-L-Thr-O-Me 
• 67-56-1 methanol 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 80465-30-1 N-carboxy 2-amino-2-butenoic acid anhydride 

Downstream Products

• 1242683-54-0 Boc-L-Phe-Z-ΔAbu(β-I)-OMe 

Relevant articles and documents

Novel stereospecific dehydration of β-hydroxy-α-amino acids using Martin's sulfurane

The stereospecific dehydration of threo-N-acyl-β-hydroxy-α-amino acid derivatives was performed using Martin's sulfurane to give (Z)-α,β-dehydroamino acids, while erythro-N-acyl-β-hydroxy-α-amino acid amides were converted to 4,5-trans-oxazolines using an

(DIETHYLAMINO)SULFUR TRIFLUORIDE (DAST) AS A USEFUL REAGENT FOR THE PREPARATION OF 2-OXAZOLINES FROM 1,2-AMIDO ALCOHOLS

Acylic 1,2-amido alcohols (6) react efficiently with a slight excess of (diethylamino)sulfur trifluoride (DAST) to afford the corresponding 2-oxazolines (10) in good yields ranging between 57-95percent.Even at the low temperature of -78 deg C, a rapid ( 1 h) and stereoselective amide cyclization is observed without formation of acylaziridine by-products.The scope of this cyclization is discussed.