873651-92-4

Basic information

• Product Name: 3-AMINO-6-PYRIDINEMETHANOL
• Synonyms: 3-AMINO-6-PYRIDINEMETHANOL;2-PYRIDINEMETHANOL, 5-AMINO-;3-Amino-6-pyridinemethanol ,97%;(5-aMinopyridin-2-yl)Methanol;5-AMino-2-(hydroxyMethyl)pyridine;(5-Amino-pyridin-2-yl)-methanol dihydrochloride;5-amino-2-pyridinemethanol
• CAS NO: 873651-92-4
• Molecular Formula: C₆H₈N₂O
• Molecular Weight: 124.14
• Mol File: 873651-92-4.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 332.7 °C at 760 mmHg
• Flash Point: 155 °C
• Appearance: /
• Density: 1.257 g/cm³
• Vapor Pressure: 5.72E-05mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 13.40±0.10(Predicted)
• CAS DataBase Reference: 3-AMINO-6-PYRIDINEMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-6-PYRIDINEMETHANOL(873651-92-4)
• EPA Substance Registry System: 3-AMINO-6-PYRIDINEMETHANOL(873651-92-4)

Safety Data

• Hazardous Substances Data: 873651-92-4(Hazardous Substances Data)

Usage

General Description

3-AMINO-6-PYRIDINEMETHANOL is a chemical compound with the molecular formula C6H8N2O. It is a white to off-white solid that is used as an intermediate in the pharmaceutical industry for the synthesis of various drugs and drug substances. It is a derivative of pyridine and contains an amino group and a hydroxyl group, making it a versatile building block for the synthesis of diverse organic compounds. 3-AMINO-6-PYRIDINEMETHANOL is also used in the production of agrochemicals and as a reagent in various chemical processes. It has potential applications in the field of medicinal chemistry, as well as in the development of new materials and catalysts.

InChI:InChI=1/C6H8N2O/c7-5-1-2-6(4-9)8-3-5/h1-3,9H,4,7H2

Upstream product

• 55338-73-3 5-amino-2-cyanopyridine 
• 39658-41-8 ethyl-6-amino-nicotinate 
• 67515-76-8 methyl 5-amino-2-pyridinecarboxylate 
• 24242-20-4 5-amino-pyridine-2-carboxylic acid 
• 323578-38-7 tert-butyl N-[6-(hydroxymethyl)pyridin-3-yl]carbamate 
• 17874-76-9 6-(methoxycarbonyl)nicotinic acid 
• 131052-40-9 methyl 5-[N-(tert-butoxycarbonyl)amino]-pyridine-2-carboxylate 
• 100-26-5 Pyridine-2,5-dicarboxylic acid 
• 119830-47-6 ethyl 3-amino-pyridine-6-carboxylate 

Downstream Products

• 1421472-13-0 phenyl 6-(hydroxymethyl)pyridin-3-ylcarbamate 

Relevant articles and documents

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The invention discloses a compound used as a protein kinase inhibitor and application of the compound, the compound has an obvious inhibition effect on protein kinase activity, can be used as a BTK inhibitor for preparing medicines for treating BTK-mediated diseases such as malignant tumors, autoimmune diseases and the like, and has wide application prospect.

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We report on a series of 4-azidobenzyloxy-substituted self-immolative linkers which undergo [3 + 2]-cycloaddition (click reaction) with functionalized trans-cyclooctenes (TCOs) at second-order rate constants in the range of 0.017 to 4.9 M-1 s-1. The choice of 4-azidobenzyloxy-substituted linker and the TCO play a critical role in the rate of all click-and-release steps, which includes the [3 + 2]-cycloaddition and subsequent degradation pathway of the triazoline to an aniline that undergoes 1,6- or 1,8-self-immolation of the phenol. We demonstrate that reacting a 4-azido-2,3,5,6-tetrafluorobenzyloxy-linker with a highly strained TCO (d-TCO) gives, to the best of our knowledge, the fastest TCO-strained alkene-azide click reaction to date (4.9 M-1 s-1), but with one caveat; release of phenol via 1,6-self-immolation is extremely slow. A methyl substituent attached to the benzyl carbon of this analogue maintains the rapid click-reaction rate, but has the added benefit of enabling the release of the phenol within hours. In an aqueous solvent at reagent concentrations in the micromolar range a maximium release was observed after 48 hours; ≈65 and ≈78percent of phenol released depending on the TCO used. The new suite of linkers and their combination with TCOs of varying structure add to the toolbox of bioorthogonal click-and-release reactions. This journal is

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