873936-98-2

Basic information

• Product Name: 2,6-Dichloro-N-methoxy-N-methylpyridine-3-carboxamide
• Synonyms: 2,6-Dichloro-N-methoxy-N-methylpyridine-3-carboxamide
• CAS NO: 873936-98-2
• Molecular Formula: C₈H₈Cl₂N₂O₂
• Molecular Weight: 235.06732
• Mol File: 873936-98-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,6-Dichloro-N-methoxy-N-methylpyridine-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dichloro-N-methoxy-N-methylpyridine-3-carboxamide(873936-98-2)
• EPA Substance Registry System: 2,6-Dichloro-N-methoxy-N-methylpyridine-3-carboxamide(873936-98-2)

Safety Data

• Hazardous Substances Data: 873936-98-2(Hazardous Substances Data)

Usage

General Description

2,6-Dichloro-N-methoxy-N-methylpyridine-3-carboxamide is a chemical compound with the molecular formula C8H8Cl2N2O2. It is a pyridine derivative and is commonly used as a pesticide and herbicide. It works by inhibiting the activity of the enzyme acetohydroxy acid synthase, which is essential for the biosynthesis of branched-chain amino acids in plants. This ultimately leads to the disruption of protein synthesis and growth, resulting in the death of the targeted plants. Additionally, the chemical has also been investigated for its potential use in the treatment of cancer, as it has shown to inhibit the growth of tumor cells in some studies. However, further research is needed to fully understand its mechanism of action and potential therapeutic applications.

Upstream product

• 38496-18-3 2,6-dichloropyridine-3-carboxylic acid 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 58584-83-1 2,6-dichloronicotinoyl chloride 

Downstream Products

• 412018-50-9 1-(4,6-dichloropyridin-3-yl)ethan-1-one 
• 1375708-67-0 1-(2,6-dichloro-pyridin-3-yl)-ethanol 
• 166525-47-9 1-(2,6-dichloropyridin-3-yl)propan-1-one 
• 1256826-72-8 6-chloro-3-methyl-1H-pyrazolo[3,4-b]pyridine 
• 873937-00-9 (2,6-Dichloro-pyridin-3-yl)-(2-methoxy-phenyl)-methanone 

Relevant articles and documents

Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer

Selective cyclooxygenase (COX)-2 inhibitors have been extensively studied for colorectal cancer (CRC) chemoprevention. Celecoxib has been reported to reduce the incidence of colorectal adenomas and CRC but is also associated with an increased risk of cardiovascular events. Here, we report a series of gut-restricted, selective COX-2 inhibitors characterized by high colonic exposure and minimized systemic exposure. By establishing acute ex vivo 18F-FDG uptake attenuation as an efficacy proxy, we identified a subset of analogues that demonstrated statistically significant in vivo dose-dependent inhibition of adenoma progression and survival extension in an APCmin/+ mouse model. However, in vitro-in vivo correlation analysis showed their chemoprotective effects were driven by residual systemic COX-2 inhibition, rationalizing their less than expected efficacies and highlighting the challenges associated with COX-2-mediated CRC disease chemoprevention.

HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions in need of inhibition of heparan sulfate biosynthesis.

RING-FUSED COMPOUND

The present invention relates to a compound that has URAT1 inhibitory action, and a URAT1 inhibitor, a blood uric acid level-reducing agent and a pharmaceutical composition comprising the compound. More specifically, the present invention relates to a compound represented by Formula (I) below. [in the formula, R1 is -Q1-A1 and the like; ---- is a double bond or a single bond; when ---- is a double bond, W1 is a nitrogen atom or a group represented by the general formula: =C(Ra)-, and W2 is a nitrogen atom or a group represented by the general formula: =C(Rb) -; when ---- is a single bond, W1 is a group represented by the general formula: -C(Raa)(Rab)- or a group represented by the general formula: -(C=O) -, and W2 is a group represented by the general formula: C(Rba)(Rbb)-, a group represented by the general formula: - (C=O) - or a group represented by the general formula: -N(Rbc)-; W3, W4 and W5 are each independently a nitrogen atom or a methine group and the like that may have a substituent; X is a single bond, an oxygen atom and the like; Y is a single bond or (CRYiRYi')n; and Z is a hydroxyl group or COOR2 and the like.