874-78-2

Basic information

• Product Name: N-(2-chloroethyl)aniline
• Synonyms: N-(2-Chloroethyl)aniline
• CAS NO: 874-78-2
• Molecular Formula: C₈H₁₀ClN*ClH
• Molecular Weight: 155.6247
• Mol File: 874-78-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 263.9°C at 760 mmHg
• Flash Point: 113.4°C
• Density: 1.137g/cm³
• Vapor Pressure: 0.01mmHg at 25°C
• Refractive Index: 1.577
• CAS DataBase Reference: N-(2-chloroethyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-chloroethyl)aniline(874-78-2)
• EPA Substance Registry System: N-(2-chloroethyl)aniline(874-78-2)

Safety Data

• Hazardous Substances Data: 874-78-2(Hazardous Substances Data)

Usage

Description

N-(2-chloroethyl)aniline, with the chemical formula C8H9ClN, is an aromatic amine that features a benzene ring with an aniline group and a chloroethyl group attached at adjacent carbon atoms. This colorless to pale yellow liquid at room temperature is widely utilized in the synthesis of pharmaceuticals and dyes.

Uses

Used in Pharmaceutical Industry:
N-(2-chloroethyl)aniline is used as a key intermediate in the synthesis of various pharmaceuticals for its reactive chloroethyl group, which allows for the creation of a range of medicinal compounds.
Used in Dye Industry:
In the dye industry, N-(2-chloroethyl)aniline is used as a precursor for the production of dyes due to its ability to form colored compounds.
Safety Precautions:
Given its classification as a potential mutagen and a suspected human carcinogen, it is crucial to handle N-(2-chloroethyl)aniline with proper safety measures. It should be used in well-ventilated areas to avoid exposure to its strong, pungent odor, and appropriate personal protective equipment should be worn to minimize health risks.

Upstream product

• 122-98-5 2-Anilinoethanol 

Downstream Products

• 696-18-4 1-phenylaziridine 
• 92435-32-0 N-[2-(5-chloro-benzothiazol-2-ylsulfanyl)-ethyl]-aniline 
• 64062-21-1 N-(2-chloroethyl)-carbanilic acid [3-(methoxycarbonylamino)-phenyl]-ester 
• 92433-95-9 N-[2-(5-chloro-benzothiazol-2-ylsulfanyl)-ethyl]-4-nitroso-aniline 
• 102164-31-8 N-(2-morpholino-ethyl)-benzanilide 
• 102552-29-4 N-(2-piperidino-ethyl)-benzanilide 
• 92699-34-8 N-(2-morpholin-4-yl-ethyl)-N-phenyl-propionamide 
• 93142-14-4 N-phenyl-N-(2-piperidin-1-yl-ethyl)-propionamide 
• 100875-64-7 N-(2-morpholino-ethyl)-acetanilide 
• 101353-64-4 N-(2-piperidino-ethyl)-acetanilide 
• 30750-87-9 (2-anilino-ethyl)-trimethyl-ammonium; chloride 
• 2038-04-2 N-(2-morpholinoethyl)aniline 
• 5319-52-8 N-[2-(piperidin-1-yl)ethyl]aniline 

Relevant articles and documents

Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents

This invention relates to 2-arylimino heterocycles, including 2-arylimino-1,3-thiazolidines, 2-arylimino-2,3,4,5-tetrahydro-1,3-thiazines, 2-arylimino-1,3-thiazolidin-4-ones, 2-arylimino-1,3-thiazolidin-5-ones, and 2-arylimino-1,3-oxazolidines, and their use in modulating progesterone receptor mediated processes, and pharmaceutical compositions for use in such therapies.