87418-77-7

Basic information

• Product Name: 5'-O-(tert-butyldimethylsilyl)uridine
• CAS NO: 87418-77-7
• Molecular Weight: 358.467
• Mol File: 87418-77-7.mol
• Article Data: 24

Chemical Properties

• CAS DataBase Reference: 5'-O-(tert-butyldimethylsilyl)uridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(tert-butyldimethylsilyl)uridine(87418-77-7)
• EPA Substance Registry System: 5'-O-(tert-butyldimethylsilyl)uridine(87418-77-7)

Safety Data

• Hazardous Substances Data: 87418-77-7(Hazardous Substances Data)

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 58-96-8 uridine 
• 1227248-63-6 C₂₀H₃₄N₂O₈Si 

Downstream Products

• 163254-10-2 1-<5'-O-(tert-Butyldimethylsilyl)-2'-O-cinnamoyl-3'-O-<(imidazol-1-yl)thiocarbonyl>-β-D-ribofuranosyl>uracil 
• 163254-08-8 1-<5'-O-(tert-Butyldimethylsilyl)-3'-O-cinnamoyl-2'-O-<(imidazol-1-yl)thiocarbonyl>-β-D-ribofuranosyl>uracil 
• 58-96-8 uridine 
• 1205121-98-7 C₂₃H₃₄N₂O₇Si 
• 1315584-44-1 5'-O-[phenyl(ethoxy-L-alaninyl)phosphoryl]uridine 
• 1315584-43-0 5'-O-[phenyl(ethoxy-L-alaninyl)phosphoryl]-2',3'-O-bis(benzyloxycarbonyl)uridine 
• 1296160-60-5 C₄₂H₅₁N₄O₉P 
• 1296160-68-3 C₃₆H₃₅Br₂N₂O₁₁PS 
• 1296160-67-2 C₃₄H₃₁Br₂N₂O₁₁PS 
• 55798-09-9 2',3'-O,N³-tribenzoyluridine 
• 1259874-66-2 C₃₅H₃₃N₂O₁₄P 
• 201664-47-3 O^5'-tert-butyldimethylsilyl-N³,O^2',O^3'-tribenzoyluridine 
• 1027158-14-0 1-<5'-O-(tert-Butyldimethylsilyl)-2',3'-dideoxy-2'-C-<2''-phenyl-1''-(N-isobutylcarbamoyl)-1''(R)-ethyl>-β-D-ribofuranosyl>uracil 
• 137410-63-0 1-<5'-O-(tert-Butyldimethylsilyl)-2'-C-<(R)carboxybenzylmethyl>-2'-deoxy-β-D-ribofuranosyl>uracil 3',2'-γ-lactone 

Relevant articles and documents

Design and synthesis of α-carboxy phosphononucleosides

Rhodium catalyzed O-H insertion reactions employing α- diazophosphonate 20 with appropriately protected thymidine, uridine, cytosine, adenosine and guanosine derivatives leads to novel 5′-phosphononucleoside derivatives. Deprotection led to a novel series of phosphono derivatives bearing a carboxylic acid moiety adjacent to the phosphonate group with potential antiviral and/or anticancer activity. The phosphononucleosides bearing an α-carboxylic acid group are envisaged as potential diphosphate mimics. Conversion to mono- and diphosphorylated phosphononucleosides has been effected for evaluation as nucleoside triphosphate mimics. Most of the novel phosphononucleosides proved to be inactive against a variety of DNA and RNA viruses. Only the phosphono AZT derivatives 56-59 showed weak activity against HIV-1 and HIV-2.

Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides

Seventeen silyl- and trityl-modified (5′-O- and 3′,5′-di-O-) nucleosides were synthesized with the aim of investigating the in vitro antiproliferative activities of these nucleoside derivatives. A subset of the compounds was evaluated at a fixed concentra

MONOMER FOR SYNTHESIS OF RNA, METHOD FOR PRODUCING SAME, AND METHOD FOR PRODUCING RNA

The objective of the present invention is to provide a monomer for RNA synthesis which can be efficiently produced and therefore by which the producing cost of RNA can be remarkably decreased, and a method for efficiently producing the monomer in a small number of steps. In addition, the objective of the present invention is also to provide a method by which RNA can be efficiently produced even when a approximately stoichiometry amount of the monomer for RNA synthesis is used. The monomer for RNA synthesis according to the present invention is represented by the following formula (I) or (I′): wherein R1 is a protective group of the hydroxy group and R2 is an alkyl group or the like.