874280-90-7

Basic information

• Product Name: rac-N-methyl-P,P-diphenyl-N-(1-phenylethyl)phosphinic amide
• Synonyms: rac-N-methyl-P,P-diphenyl-N-(1-phenylethyl)phosphinic amide
• CAS NO: 874280-90-7
• Molecular Weight: 335.386
• Mol File: 874280-90-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: rac-N-methyl-P,P-diphenyl-N-(1-phenylethyl)phosphinic amide(CAS DataBase Reference)
• NIST Chemistry Reference: rac-N-methyl-P,P-diphenyl-N-(1-phenylethyl)phosphinic amide(874280-90-7)
• EPA Substance Registry System: rac-N-methyl-P,P-diphenyl-N-(1-phenylethyl)phosphinic amide(874280-90-7)

Safety Data

• Hazardous Substances Data: 874280-90-7(Hazardous Substances Data)

Upstream product

• 1499-21-4 Diphenylphosphinic chloride 
• 618-36-0 rac-methylbenzylamine 
• 62369-76-0 P-diphenyl(N-benzyl-N-methyl)-λ⁵-phosphinamide 
• 74-88-4 methyl iodide 
• 67764-56-1 (RS)-N-(1-phenylethyl)-P,P-diphenylphosphinamide 

Relevant articles and documents

Phosphinamide-directed benzylic lithiation. application to the synthesis of peptide building blocks

N-Benzyldiphenylphosphinamides are deprotonated at the NCα position diastereospecifically upon treatment with f-BuLi in diethyl ether at low temperature. The reaction of the anions with alkyl, acyl, and tin halides, aliphatic and aromatic aldehydes, and Michael acceptors allowed installation of a variety of functional groups into the benzylic arm in excellent yields. Cleavage of the P-N linkage affords 1,2-amino alcohols and α-, β-, and γ-amino acids.

Unprecedented asymmetric induction through configurationally stable lithium N-(α-methylbenzyl)phosphinamides. A new entry to enantiomerically pure γ-aminophosphinic acids and esters

The first examples of configurationally stable N-benzyl-N-phosphinoyl carbanions are described. Their applications to the synthesis of homochiral γ-aminophosphinic acids and esters via highly enantioselective dearomatising reactions are shown. The Royal S