874289-46-0 Usage
General Description
5-(Dimethylcarbamoyl)-2-fluorobenzeneboronic acid is a chemical compound with the formula C10H13BFNO3. It is a boronic acid derivative used in organic synthesis as a building block for various pharmaceutical and agrochemical compounds. This chemical is commonly used in the field of medicinal chemistry for the synthesis of potential drug candidates. It is a white solid that is soluble in organic solvents and has a melting point of around 108-110°C. The compound has applications in the formation of carbon-carbon and carbon-heteroatom bonds, making it a versatile and valuable reagent in chemical synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 874289-46-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,4,2,8 and 9 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 874289-46:
(8*8)+(7*7)+(6*4)+(5*2)+(4*8)+(3*9)+(2*4)+(1*6)=220
220 % 10 = 0
So 874289-46-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H11BFNO3/c1-12(2)9(13)6-3-4-8(11)7(5-6)10(14)15/h3-5,14-15H,1-2H3
874289-46-0Relevant articles and documents
Fast and Tight Boronate Formation for Click Bioorthogonal Conjugation
Akgun, Burcin,Hall, Dennis G.
, p. 3909 - 3913 (2016)
A new click bioorthogonal reaction system was devised to enable the fast ligation (kON≈340 m-1 s-1) of conjugatable derivatives of a rigid cyclic diol (nopoldiol) and a carefully optimized boronic acid partner, 2-methyl-5-carboxymethylphenylboronic acid. Using NMR and fluorescence spectroscopy studies, the corresponding boronates were found to form reversibly within minutes at low micromolar concentration in water, providing submicromolar equilibrium constant (Keq≈105-106 m-1). Efficient protein conjugation under physiological conditions was demonstrated with model proteins thioredoxin and albumin, and characterized by mass spectrometry and gel electrophoresis.
