87440-45-7

Basic information

• Product Name: TAPROSTENE SODIUM
• Synonyms: Sodium 3-[(Z)-[(3aR,4R,5R,6aS)-4-[(1E,3S)-3-cyclohexyl-3-hydroxy-1-propenyl]hexahydro-5-hydroxy-2H-cyclopenta[b]furan-2-ylidene]methyl]benzoate;taprostene sodium salt;Rheocyclan, Sodium 3-[(Z)-[(3aR,4R,5R,6aS)-4-[(1E,3S)-3-cyclohexyl-3-hydroxy-1-propenyl]hexahydro-5-hydroxy-2H-cyclopenta[b]furan-2-ylidene]methyl]benzoate;3-[[(2Z,3aR)-4β-[(1E,3S)-3-Cyclohexyl-3-hydroxy-1-propenyl]-3,3aβ,4,5,6,6aβ-hexahydro-5α-hydroxy-2H-cyclopenta[b]furan-2-ylidene]methyl]benzenecarboxylic acid sodium salt;CG-4203;2,3,4-Trinor-1,5-inter-2-phenylene-6,9-epoxy-11,15-dihydroxy-15-dihydroxy-15-cyclohexyl-(16,17,18,19,20-pentanor)prosta-5,13-dienoate;Benzoic acid, 3-((4-(3-cyclohexyl-3-hydroxy-1-propenyl)hexahydro-5-hydroxy-2H-cyclopenta(B)furan-2-ylidene)methyl)-, monosodium salt, (3ar-(2Z,3aalpha,4alpha(1E,3S*),5beta,6aalpha))-;Benzoic acid, 3-((Z)-((3ar,4R,5R,6as)-(4-((1E,3S)-3-cyclohexyl-3-hydroxy-1-propenyl)hexahydro-5-hydroxy-2H-cyclopenta(B)furan-2-ylidene)methyl)-, monosodium salt
• CAS NO: 87440-45-7
• Molecular Formula: C24H29O5.Na
• Molecular Weight: 420.478
• Mol File: 87440-45-7.mol
• Article Data: 0

Chemical Properties

• Melting Point: 173-182.5 °C(lit.)
• Boiling Point: 609.4°Cat760mmHg
• Flash Point: 209.2°C
• Appearance: off-white/
• Density: g/cm³
• Vapor Pressure: 1.06E-15mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: H2O: 26 mg/mL
• CAS DataBase Reference: TAPROSTENE SODIUM(CAS DataBase Reference)
• NIST Chemistry Reference: TAPROSTENE SODIUM(87440-45-7)
• EPA Substance Registry System: TAPROSTENE SODIUM(87440-45-7)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36
• WGK Germany: 3
• Hazardous Substances Data: 87440-45-7(Hazardous Substances Data)

Usage

Description

Taprostene Sodium, also known as Taprostene Sodium Salt, is a selective prostanoid receptor IP1 agonist and a Prostacyclin analogue, an eicosanoid that prevents the formation of platelet plugs. It is a synthetic compound that mimics the action of prostacyclin, a naturally occurring hormone in the body that plays a crucial role in maintaining vascular homeostasis and preventing blood clot formation.

Uses

Used in Pharmaceutical Industry:
Taprostene Sodium is used as a pharmaceutical agent for the treatment of pulmonary arterial hypertension (PAH). It helps to improve blood flow and reduce the pressure in the pulmonary arteries, thereby alleviating the symptoms and complications associated with PAH.
Used in Cardiovascular Applications:
Taprostene Sodium is used as a cardiovascular agent for the prevention of platelet aggregation and blood clot formation. Its ability to activate the prostanoid receptor IP1 helps to maintain vascular homeostasis and prevent the formation of platelet plugs, thereby reducing the risk of thrombotic events.
Used in Research Applications:
Taprostene Sodium is used as a research tool for studying the role of prostacyclin and its receptors in various physiological and pathological processes. It can be used to investigate the mechanisms of platelet aggregation, blood clot formation, and vascular homeostasis, as well as to explore the potential therapeutic applications of prostacyclin analogues in various diseases and conditions.

InChI:InChI=1/C24H30O5.Na/c25-21(16-6-2-1-3-7-16)10-9-19-20-13-18(29-23(20)14-22(19)26)12-15-5-4-8-17(11-15)24(27)28;/h4-5,8-12,16,19-23,25-26H,1-3,6-7,13-14H2,(H,27,28);/q;+1/p-1/b10-9+,18-12-;/t19-,20-,21-,22-,23+;/m1./s1