87444-41-5

Basic information

• Product Name: 6-Bromo-2-methylthiazolo[5,4-b]pyrazine
• Synonyms: 6-bromo-2-methylthiazolo[5,4-b]pyrazine;6-bromo-2-methyl[1,3]thiazolo[4,5-b]pyrazine
• CAS NO: 87444-41-5
• Molecular Formula: C6H4BrN3S
• Molecular Weight: 230.09
• Mol File: 87444-41-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 158 °C
• Boiling Point: 293 °C
• Flash Point: 131 °C
• Appearance: /
• Density: 1.838
• Refractive Index: 1.717
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-Bromo-2-methylthiazolo[5,4-b]pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromo-2-methylthiazolo[5,4-b]pyrazine(87444-41-5)
• EPA Substance Registry System: 6-Bromo-2-methylthiazolo[5,4-b]pyrazine(87444-41-5)

Safety Data

• Hazardous Substances Data: 87444-41-5(Hazardous Substances Data)

Usage

General Description

6-Bromo-2-methylthiazolo[5,4-b]pyrazine is a compound with the molecular formula C6H5BrN2S. It is a heterocyclic organic compound consisting of a five-membered thiazole ring fused to a six-membered pyrazine ring. The presence of a bromine atom and a methyl group on the thiazole ring gives this compound its unique chemical properties. It is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals due to its potential as a ligand in coordination chemistry and its ability to act as a versatile precursor for the preparation of diverse functionalized compounds. Its structure and reactivity make it a valuable intermediate in the production of various biologically active molecules. Additionally, it has been studied for its potential therapeutic applications in the treatment of certain diseases.

InChI:InChI=1/C6H4BrN3S/c1-3-9-5-6(11-3)10-4(7)2-8-5/h2H,1H3

Upstream product

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Relevant articles and documents

Knoevenagel Condensation between 2-Methyl-thiazolo[4,5-b]pyrazines and Aldehydes

Knoevenagel condensation, an olefin-forming reaction from active methyl/methylene-containing compounds and aldehydes, is a fundamental and useful synthetic method. Benzothiazoles are, however, out of the scope of Knoevenagel condensation. Here, we report that Knoevenagel condensation between aldehydes and 2-methyl-thiazolo[4,5-b]pyrazines (MeTPy), a fused ring structure comprising pyrazine and thiazole, proceeded smoothly, despite minor structural differences from benzothiazoles. This finding will be useful for short synthesis of MeTPy-containing functional molecules, such as a tau probe analog 1.

Purine analogues as amplifiers of phleomycin. VIII. Some thiazolo[4,5-b]pyrazines and related compounds

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