87453-29-0

Basic information

• Product Name: (2-fluoro-1-fluoromethyl-ethyl)-benzene
• Synonyms: (2-fluoro-1-fluoromethyl-ethyl)-benzene
• CAS NO: 87453-29-0
• Molecular Weight: 156.175
• Mol File: 87453-29-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2-fluoro-1-fluoromethyl-ethyl)-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (2-fluoro-1-fluoromethyl-ethyl)-benzene(87453-29-0)
• EPA Substance Registry System: (2-fluoro-1-fluoromethyl-ethyl)-benzene(87453-29-0)

Safety Data

• Hazardous Substances Data: 87453-29-0(Hazardous Substances Data)

Upstream product

• 4165-96-2 3-phenylglutaric acid 
• 100-42-5 styrene 

Relevant articles and documents

Copper-Catalyzed Regioselective Borylfluoromethylation of Alkenes

A copper-catalyzed borylfluoromethylation of alkenes with fluoromethyl iodide and diboron reagents was disclosed. This protocol afforded the previously unknown and synthetically useful borylfluoromethylated alkanes in good yields and excellent regioselectivity. Its synthetic application was illustrated through the derivatization of organoboron products and preparation of monofluorinated ibuprofen.

ARYLSULFONYLMETHYL OR ARYLSULFONAMIDE SUBSTITUTED AROMATIC COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MADULATION OF THE DOPAMINE D3 RECEPTOR

The present invention relates to aromatic compounds of the formula (I), wherein Ar is phenyl or an aromatic 5- or 6-membered C-bound heteroaromatic radical, wherein Ar may carry 1 radical Ra and wherein Ar may also carry 1 or 2 radicals Rb; X is N or CH; Y is O, S, -CH=N-, -CH=CH- or -N=CH-; A is CH2i O or S; E is CR6R7 or NR 3; R1 is C1-C4-alkyl, C3-C4-cycloalkyl, C3-C4-cycloalkylmethyl, C3-C4-alkenyl, fluorinated C1-C4--alkyl, fluorinated C3-C4-cycloalkyl, fluorinated C3-C4-cycloalkylmethyl, fluorinated C3-C4--alkenyl, formyl or C,-C3-alkylcarbonyl; R1a is H, C2-C4-alkyl, C3-C4-cycloalkyl, C3-C4-alkenyl, fluorinated C1-C4-alkyl, fluorinated C3-C4 -cycloalkyl, or R1a and R2 together are (CH2)n with n being 2 or 3, or R1a and R2a together are (CH2)n with n being 2 or 3; R2 and R2a are independently of each other H, CH3, CH2F, CHF2 or CF3; R3 is H or C1-C4-alkyl; R6, R7 independently of each other are selected from H, C1-C2-alkyl and fluorinated C1-C2-alkyl; and the physiologically tolerated acid addition salts thereof. The invention also relates to the use of a compound of the formula I or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for the treatment of a medical disorder susceptible to treatment with a dopamine D3 receptor ligand.