87462-12-2

Basic information

• Product Name: N,N-Bisisopropyl-3-phenyl-2-propenaMine
• Synonyms: N,N-Bisisopropyl-3-phenyl-2-propenaMine;N,N-Bis(1-Methylethyl)-3-phenyl-2-propen-1-aMine;Tolterodine IMpurity B
• CAS NO: 87462-12-2
• Molecular Formula: C₁₅H₂₃N
• Molecular Weight: 217.34982
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 87462-12-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: N,N-Bisisopropyl-3-phenyl-2-propenaMine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-Bisisopropyl-3-phenyl-2-propenaMine(87462-12-2)
• EPA Substance Registry System: N,N-Bisisopropyl-3-phenyl-2-propenaMine(87462-12-2)

Safety Data

• Hazardous Substances Data: 87462-12-2(Hazardous Substances Data)

Usage

Description

N,N-Bisisopropyl-3-phenyl-2-propenamine, also known as Tolterodine impurity B, is a chemical compound that is an impurity found in Tolterodine (T535800). It is characterized by its brown oil appearance.

Uses

Used in Pharmaceutical Industry:
N,N-Bisisopropyl-3-phenyl-2-propenamine is used as an impurity in Tolterodine, which is a medication used for treating overactive bladder and urinary incontinence. The presence of this impurity in Tolterodine may affect the quality, safety, and efficacy of the drug. Therefore, it is important to monitor and control the levels of this impurity during the manufacturing process to ensure the safety and effectiveness of the medication.

Upstream product

• 100-42-5 styrene 
• 50-00-0 formaldehyd 
• 108-18-9 diisopropylamine 
• 2687-12-9 cinnamyl chloride 
• 673-32-5 1-Phenylprop-1-yne 
• 110-88-3 1,3,5-Trioxan 

Downstream Products

• 1076199-77-3 racemic 3-(3-N,N'-diisopropylamino-1-phenyl-propyl)-4-hydroxy-benzoic acid 
• 250214-44-9 2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxyl-methyl)phenyl isobutyrate 
• 4439-45-6 1,6-diphenyl-hexa-1,5-diene 
• 156755-20-3 PNU 200577 l-mandelate salt 
• 286930-02-7 fesoterodine 
• 200801-70-3 RS-N,N-diisopropyl-3-(2-hydroxy-5-(hydroxymethyl)phenyl)-3-phenylpropylamine 
• 207679-81-0 (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)-phenol 

Relevant articles and documents

Process for preparation of 3-(2-hydroxy-5-substituted phenyl)-3-phenylpropylamines, intermediates for making hydroxytolterodine

A process is described for the preparation of 3-(5-formyl-2-hydroxyphenyl)-3-phenylpropylamine derivatives, intermediates which can be used for preparation of agents for urinary incontinence therapy, specifically to 2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol and its prodrugs.

PROCESS FOR OBTAINING 3,3-DIPHENYLPROPYLAMINES

The invention relates to a process for obtaining 3,3- diphenylpropylamines of general formula (I), particularly Fesoterodine, as well as their enantiomers, solvates and salts, comprising a chemoselective reduction of the acid group against the ester group

Allylic amination of internal alkynes with aromatic and aliphatic amines using polymer-supported triphenylphosphane-palladium complex as a heterogeneous and recyclable catalyst

A facile and novel protocol for the allylic amination of internal alkynes with amines by using a polymer-supported triphenylphosphane-palladium complex [PS-TPP-Pd] as a highly active heterogeneous reusable catalyst was developed. The catalyst exhibited remarkable activity and is re-usable over five consecutive cycles. The protocol was applicable for a variety of hindered and functionalized aromatic/ aliphatic amines and afforded the desired allylic products in good to excellent yield.