87491-79-0

Basic information

• Product Name: 1-[(CHLOROMETHYL)SULFONYL]NAPHTHALENE
• Synonyms: 1-[(CHLOROMETHYL)SULFONYL]NAPHTHALENE;1-[(chloroMethyl)sulfonyl]naphathalene
• CAS NO: 87491-79-0
• Molecular Formula: C₁₁H₉ClO₂S
• Molecular Weight: 240.7
• Product Categories: API intermediates
• Mol File: 87491-79-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 441.564 °C at 760 mmHg
• Flash Point: 220.85 °C
• Appearance: /
• Density: 1.362 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.626
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-[(CHLOROMETHYL)SULFONYL]NAPHTHALENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(CHLOROMETHYL)SULFONYL]NAPHTHALENE(87491-79-0)
• EPA Substance Registry System: 1-[(CHLOROMETHYL)SULFONYL]NAPHTHALENE(87491-79-0)

Safety Data

• Hazardous Substances Data: 87491-79-0(Hazardous Substances Data)

Usage

General Description

1-[(Chloromethyl)sulfonyl]naphthalene is a chemical compound with the molecular formula C11H9ClO2S. It is a naphthalene derivative that contains a chloromethylsulfonyl functional group, which is often used as a reagent in organic synthesis. 1-[(CHLOROMETHYL)SULFONYL]NAPHTHALENE is a white to off-white solid with a high melting point, making it useful for various industrial applications. The chloromethylsulfonyl group is known for its ability to react with nucleophiles, making 1-[(chloromethyl)sulfonyl]naphthalene a versatile building block for the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is important to handle this compound with care, as the chloromethylsulfonyl group can be reactive and potentially hazardous if not used properly.

InChI:InChI=1/C11H9ClO2S/c12-8-15(13,14)11-7-3-5-9-4-1-2-6-10(9)11/h1-7H,8H2

Upstream product

• 74-97-5 chlorobromomethane 
• 85-46-1 1-Naphthalenesulfonyl chloride 

Downstream Products

• 925450-40-4 1-[3-(2-chloro-ethoxy)-2-nitro-phenyl-methanesulfonyl]-naphthalene 
• 925450-82-4 2-[3-(naphthalen-1-ylsulfonylmethyl)-4-nitrophenyl][1,3]dioxolane 
• 928782-43-8 4-[3-(1-Naphthylsulfonylmethyl)-4-nitrophenoxymethyl]piperidine-1-carboxylic acid benzyl ester 
• 1253422-90-0 C₂₂H₂₂ClN₃O₄S 
• 1086838-51-8 (R)-t-butyl 1-{[3-(naphth-1-ylsulfonyl)methyl]-4-nitrophenyl}pyrrolidin-3-ylcarbamate 
• 1232361-11-3 C₂₆H₂₉N₃O₆S 
• 1199795-12-4 1-methyl-4-{4-nitro-3-[(1-naphthalenesulfonyl)methyl]phenyl}piperazine 
• 1086838-55-2 t-butyl 1-{3-[(naphth-1-ylsulfonyl)methyl]-4-nitrophenyl}-piperidin-4-ylcarbamate 
• 952501-26-7 1-[3-(2-Chloro-1-chloromethyl-ethoxy)-2-nitro-phenylmethane-sulfonyl]-naphthalene 
• 928782-47-2 1-Benzyl-3-[3-(1-Naphthylsulfonylmethyl)-4-nitrophenoxy]-piperidine 
• 928782-38-1 1-Benzyl-4-[3-(1-naphthylsulfonylmethyl)-4-nitrophenoxy]piperidine 
• 928782-34-7 1-benzyl-3-[3-(naphthalene-1-sulfonylmethyl)-4-nitro-phenoxy]-pyrrolidine 
• 925450-54-0 1-[3-(2-chloro-ethoxy)-5-methoxy-2-nitro-phenylmethanesulfonyl]-naphthalene 
• 925450-48-2 1-[3-(2-chloro-ethoxy)-5-fluoro-2-nitro-phenylmethanesulfonyl]-naphthalene 

Relevant articles and documents

Chloromethyl sulfones from sulfonyl chlorides via a one-pot procedure

A simplified one-pot transformation of a diverse set of aryl- and heteroaryl-sulfonyl chlorides into the corresponding chloromethyl sulfones is described.

AMINOAZACYCLYL-3-SULFONYLINDAZOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS

The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.

Azinyl-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands

The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.