87496-32-0

Basic information

• Product Name: 1-Hydroxymethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbothioic acid phenylamide
• CAS NO: 87496-32-0
• Molecular Weight: 358.461
• Mol File: 87496-32-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Hydroxymethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbothioic acid phenylamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Hydroxymethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbothioic acid phenylamide(87496-32-0)
• EPA Substance Registry System: 1-Hydroxymethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbothioic acid phenylamide(87496-32-0)

Safety Data

• Hazardous Substances Data: 87496-32-0(Hazardous Substances Data)

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 486-99-7 (6,7-dimethoxy-1,2,3,4-tetrahydro-1-isoquinolyl)methanol 

Relevant articles and documents

SATURATED HETEROCYCLES. 47. SYNTHESIS OF SOME TETRAHYDROISOQUINOLINE CONDENSED 1,3-HETEROCYCLES

Calycotomine (2) and homocalycotomine (3) reacted with isothiocyanates to give the corresponding thiocarbamides (4, 5).The latter were treated with methyl iodide, and subsequent elimination of methyl mercaptan on treatment with alkali afforded 1,3-oxazolo-isoquinolines (6) and 1,3-oxazinoisoquinolines(7). 1,3-Thiazoloisoquinolines (8) and 1,3-thiazinoisoquinolines (9) were prepared from 4 and 5 with hydrogen chloride.Compound 7a was also synthetised by the reaction of 3 with phenyl isocyanate, followed by the elimination of water; 9a was obtainable from 7a by treatment with P4S10.The structures of compounds 6-9 were confirmed by 1H NMR.