875515-86-9Relevant articles and documents
Water-soluble prodrugs of the human immunodeficiency virus protease inhibitors lopinavir and ritonavir
Degoey, David A.,Grampovnik, David J.,Flosi, William J.,Marsh, Kennan C.,Wang, Xiu C.,Klein, Larry L.,McDaniel, Keith F.,Liu, Yaya,Long, Michelle A.,Kati, Warren M.,Molla, Akhteruzzaman,Kempf, Dale J.
experimental part, p. 2964 - 2970 (2010/02/28)
We studied the synthesis, cleavage rates, and oral administration of prodrugs of the HIV protease inhibitors (PIs) lopinavir and ritonavir. Phosphate esters attached directly to the central hydroxyl groups of these PIs did not demonstrate enzyme-mediated
