875631-01-9Relevant articles and documents
Synthetic study of tautomycin. Part 2: Synthesis of Ichihara's fragment based on regioselective enzymatic acetylation of complex molecule
Ishii, Yusuke,Nagumo, Shinji,Arai, Takayuki,Akuzawa, Masami,Kawahara, Norio,Akita, Hiroyuki
, p. 716 - 725 (2007/10/03)
Formal synthesis of tautomycin, which inhibits type 1 and type 2A protein phosphatases, was achieved. Spiroketal diol 21 was synthesized from alcohol 2 or 11. The regioselective enzymatic acetylation of 21 with the lipase 'Amano PS' gave monoacetate 23 in